{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:40Z","timestamp":1791417640000,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Allanblackia floribunda<\/jats:italic> has been used to treat an upset stomach in African traditional medicine, but its efficacy and safety have not been scientifically studied. The present research is aimed at assessing the antiulcer property of the seed extract of the plant to validate its traditional claim. Rats were pretreated with three doses of aqueous extract of <jats:italic>A<\/jats:italic>. <jats:italic>floribunda<\/jats:italic> (AFE) at 30, 100, and 300\u2009mg\/kg or omeprazole 10\u2009mg\/kg for 1 hr before the acute gastric ulcer was induced by oral administration of 5\u2009mL\/kg of 98% ethanol. The animals were sacrificed under anesthesia, and the stomach and blood were collected. The gross histology of the stomach, percentage protection conferred by the treatment, gastric pH, and serum TNF\u2010<jats:italic>\u03b1<\/jats:italic> and INF\u2010<jats:italic>\u03b3<\/jats:italic> were assessed as well as the expression of Ki67 antigens. The antioxidant properties as well as the acute toxicity profile of the plant extract were also assessed. The results show that <jats:italic>A<\/jats:italic>. <jats:italic>floribunda<\/jats:italic> conferred significant protection on the rats against gastric ulceration with % protection of 46.15, 57.69, and 65.38 for AFE 30, 100, and 300\u2009mg\/kg, respectively, as well as 69.23% for omeprazole 10\u2009mg\/kg. The plant extract caused marked reductions in gastric pH, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and INF\u2010<jats:italic>\u03b3<\/jats:italic> with statistical significance (<jats:italic>p<\/jats:italic> &lt; 0.001) for AFE 300\u2009mg\/kg and omeprazole 10\u2009mg\/kg. Also, the plant showed good antioxidant activity comparable to gallic acid. Furthermore, the plant extract modulated the expression of Ki67 antigens. All animals survived the 14\u2010day delayed toxicity test with no significant differences in physical, hematological, and biochemical parameters between rats orally administered with supratherapeutic doses of AFE (5000\u2009mg\/kg) or normal saline. The study established that the gastroprotective effect of the seed extract of <jats:italic>A<\/jats:italic>. <jats:italic>floribunda<\/jats:italic> is attributable to its antisecretory, antioxidant, and anti\u2010inflammatory properties. Additionally, the plant was found to promote ulcer healing via the modulation of the expression Ki67 and was safe at supratherapeutic doses.<\/jats:p>","DOI":"10.1155\/2021\/6694572","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T21:47:39Z","timestamp":1610488059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<i>Allanblackia floribunda<\/i> Seed Extract Attenuates the Ethanol\u2010Induced Gastric Ulcer in Rats via the Inhibition of TNF\u2010<i>\u03b1<\/i> and INF\u2010<i>\u03b3<\/i> Levels and Modulation in the Expression of Ki67 Protein"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-1147","authenticated-orcid":false,"given":"Francis Ackah","family":"Armah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6830-0283","authenticated-orcid":false,"given":"Isaac Tabiri","family":"Henneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-7722","authenticated-orcid":false,"given":"John","family":"Alake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wisdom","family":"Ahlidja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-3033","authenticated-orcid":false,"given":"Benjamin","family":"Amoani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Gyamerah","family":"Ofori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baffour","family":"Asante-Kyei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1932-7519","authenticated-orcid":false,"given":"Gbadamosi Ismail","family":"Temitayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4341-3361","authenticated-orcid":false,"given":"Christian Kweku","family":"Adokoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2017.037"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60938-7"},{"key":"e_1_2_9_3_2","first-page":"1005","article-title":"Peptic ulcer disease","volume":"76","author":"Ramakrishnan K.","year":"2007","journal-title":"American Family Physician"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-017-9947-0"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/796405"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.22270\/jddt.v6i3.1210"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.5897\/sre11.775"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/786426"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2019.1582639"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160922333"},{"key":"e_1_2_9_11_2","first-page":"1","article-title":"A tree reference and selection guide version 4.0","author":"Orwa C.","year":"2009","journal-title":"Agroforestree Database"},{"key":"e_1_2_9_12_2","volume-title":"Woody Plant of Ghana","author":"Irvine F.","year":"1961"},{"key":"e_1_2_9_13_2","first-page":"21","article-title":"Anti-inflammatory properties of the fruits of Allanblanckia floribunda oliv. 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