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However, the regulatory effect of PTX on inflammatory cytokines is unclear. Autophagy can regulate the activation of inflammasomes and then inhibit inflammation as previously described. Our study attempts to explore the relationship between autophagy and PTX\u2010mediated regulation of inflammasome suppression. Macrophage\u2010like RAW264.7 cells were studied as the <jats:italic>in vitro<\/jats:italic> macrophage model. We investigated the anti\u2010inflammatory effect caused by PTX with time and dose response against the LPS\u2010induced inflammatory factors (TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>). Western blot detected the levels of autophagy\u2010related proteins Beclin\u20101 and LC3, as well as the signal pathways of AMPK and p\u2010AMPK. Fluorescence microscope and transmission electron microscope were used to observe the autophagy bodies in cells influenced by PTX. The autophagy in cells inhibited by PTX exhibited dose\u2010 and time\u2010dependent effects, and PTX alleviated LPS\u2010induced inflammation caused by retarded autophagy. Furthermore, in RAW264.7 macrophage cells, our data indicated that AMPK signaling perhaps functioned importantly in repressed autophagy. In addition, in RAW264.7 macrophages, our data suggested that AMPK signaling might play an important role in inhibiting autophagy during the process of PTX ameliorating LPS\u2010mediated inflammation.<\/jats:p>","DOI":"10.1155\/2021\/6698366","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T23:20:12Z","timestamp":1615936812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["[Retracted] Pentoxifylline Can Reduce the Inflammation Caused by LPS after Inhibiting Autophagy in RAW264.7 Macrophage Cells"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3113-9692","authenticated-orcid":false,"given":"Danping","family":"Ruan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9962-9818","authenticated-orcid":false,"given":"Zhonglong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-7801","authenticated-orcid":false,"given":"Jie","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.016"},{"key":"e_1_2_8_3_2","volume-title":"Macrophages and inflammation. 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