{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T09:48:50Z","timestamp":1781344130440,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473523"],"award-info":[{"award-number":["81473523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2015BAI04B00"],"award-info":[{"award-number":["2015BAI04B00"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science and Technology Pillar Program during the Twelfth Five-year Plan Period of China","award":["81473523"],"award-info":[{"award-number":["81473523"]}]},{"name":"National Science and Technology Pillar Program during the Twelfth Five-year Plan Period of China","award":["2015BAI04B00"],"award-info":[{"award-number":["2015BAI04B00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,5,3]]},"abstract":"<jats:p>Background. The treatment effects and safety of ear acupressure (EAP) for patients with allergic rhinitis (AR) have yet to be clarified. Objective. To evaluate the effects and safety of EAP in AR patients. Design. Systematic review of published studies. Methods. A total of 24 English and Chinese databases (PubMed, EMBASE (Excerpta Medical Database), Cochrane Central Register of Controlled Trials, CINAHL, Informit, ScienceDirect, LILACS (Latin American and Caribbean Health Sciences), ProQuest, AMED, Blackwell Synergy, PsycINFO, Panteleimon, AcuBriefs, KoreaMed, IndMed, Ingenta, mRCT, ISI Web of Knowledge, ERIC, VIP Information (http:\/\/www.cqvip.com), China National Knowledge Infrastructure (http:\/\/www.cnki.net), Cochrane Library, Chinese Cochrane Centre Controlled Trials Register Platform, and Wanfang Chinese Digital Periodical and Conference Database) were searched from their respective inceptions to August 2020 to collect randomized controlled trials of ear acupressure for allergic rhinitis. We performed literature inclusion, data extraction, and trial quality evaluations. Methodological quality was assessed according to the Cochrane Handbook. Revman5.3 was used for all analyses. Results. A total of 203 trials were identified and eleven studies involved 1094 participants aged 3\u201370 years. EAP was better than control group interventions in terms of effectiveness (risk ratio (RR): 0.51; 95% confidence interval (CI): 0.36\u20130.70; <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.0001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). EAP was superior to sham EAP in terms of improvement of the total nasal symptom score (RR: \u22120.50; 95% CI: \u22120.96\u20130.05; P\u2009=\u20090.03), sneezing score (RR: \u22120.36; 95% CI: \u22120.59\u20130.12; P\u2009=\u20090.003), global QoL score (RR: 0.42; 95% CI: 0.04\u20130.08; P\u2009=\u20090.03), and eye symptom score (RR: \u22120.36; 95% CI: \u22120.67\u20130.05; P\u2009=\u20090.02). Conclusions. Despite the positive results, it is premature to confirm the efficacy of EAP for treating AR. More high-quality studies are needed to confirm safety and efficacy.<\/jats:p>","DOI":"10.1155\/2021\/6699749","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T16:50:18Z","timestamp":1620060618000},"page":"1-20","source":"Crossref","is-referenced-by-count":6,"title":["Ear Acupressure for Allergic Rhinitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7805-0185","authenticated-orcid":true,"given":"Juan","family":"Zhong","sequence":"first","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqin","family":"Liu","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5430-1736","authenticated-orcid":true,"given":"Dan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, No. 25 TaiPing Street, Luzhouv 646000, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0931-1257","authenticated-orcid":true,"given":"Tao","family":"Lu","sequence":"additional","affiliation":[{"name":"Otolaryngology and Head & Neck Surgery Department One, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0356-1420","authenticated-orcid":true,"given":"Yifeng","family":"Shen","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1183-8015","authenticated-orcid":true,"given":"Qisheng","family":"Gong","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijia","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8746-0277","authenticated-orcid":true,"given":"Qinxiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, China"},{"name":"School of Medical and Life Sciences\/Reproductive & Women-Children Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8132798"},{"issue":"5 Suppl","key":"2","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1067\/mai.2001.118891","article-title":"allergic rhinitis and its impact on asthma","volume":"108","author":"J. 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