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It is also an important risk factor for the development of degenerative and angiogenic diseases. However, the molecular mechanisms involved in the process of aging in the retina remain largely elusive. This study investigated the role of mTORC1 signaling in aging of the retina. We showed that mTORC1 was activated in old\u2010aged retina, particularly in the ganglion cells. The role of mTORC1 activation was further investigated in <jats:italic>Chx10-Cre;Tsc1<jats:sup>fx\/fx<\/jats:sup><\/jats:italic> mouse (<jats:italic>Tsc1<\/jats:italic>\u2010cKO). Activation of mTORC1 was found in bipolar and some of the ganglion and amacrine cells in the adult <jats:italic>Tsc1<\/jats:italic>\u2010cKO retina. Bipolar cell hypertrophy and M\u00fcller gliosis were observed in <jats:italic>Tsc1<\/jats:italic>\u2010cKO since 6 weeks of age. The abnormal endings of bipolar cell dendritic tips at the outer nuclear layer resembled that of the old\u2010aged mice. Microglial cell activation became evident in 6\u2010week\u2010old <jats:italic>Tsc1<\/jats:italic>\u2010cKO. At 5 months, the <jats:italic>Tsc1<\/jats:italic>\u2010cKO mice exhibited advanced features of old\u2010aged retina, including the expression of p16<jats:sup>Ink4a<\/jats:sup> and p21, expression of SA\u2010<jats:italic>\u03b2<\/jats:italic>\u2010gal in ganglion cells, decreased photoreceptor cell numbers, decreased electroretinogram responses, increased oxidative stress, microglial cell activation, and increased expression of immune and inflammatory genes. Inhibition of microglial cells by minocycline partially prevented photoreceptor cell loss and restored the electroretinogram responses. Collectively, our study showed that the activation of mTORC1 signaling accelerated aging of the retina by both cell autonomous and nonautonomous mechanisms. Our study also highlighted the role of microglia cells in driving the decline in retina function.<\/jats:p>","DOI":"10.1155\/2021\/6715758","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T20:20:11Z","timestamp":1636143611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["mTORC1 Activation in <i>Chx10<\/i>\u2010Specific <i>Tsc1<\/i> Knockout Mice Accelerates Retina Aging and 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