{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:44:29Z","timestamp":1747190669109,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2021,12,13]]},"abstract":"<jats:p>Objective. To explore the application of evidence-based nursing intervention in the treatment of advanced squamous cell carcinoma of the lung by erlotinib combined with tegafur, gimeracil, and oteracil potassium (TS-1) and its influence on quality of life (QOL). Methods. Clinical data of 92 patients with advanced squamous cell carcinoma of the lung treated with erlotinib and TS-1 in our hospital (January 2017\u2013January 2021) were retrospectively analyzed. Forty-six patients receiving conventional nursing were set as the control group (CG), and other 46 patients receiving evidence-based nursing intervention additionally were set as the study group (SG). The clinical observation indexes of the two groups were compared and analyzed. Results. No obvious difference in general data between both groups (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). According to EORTC QLQ-C30, compared with the CG, the scores of role function, physical function, social function, cognitive function, and emotional function in the SG were remarkably higher (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). After intervention, scores of VAS of patients were obviously lower than those before intervention (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>), and scores of VAS in the SG after intervention were obviously lower than those in the CG (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). After intervention, scores of SAS and SDS were lower than those before intervention, and those of the SG were obviously lower than those of the SG (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). Compared with the CG, incidences of adverse reactions such as diarrhoea, nausea and vomiting, erythra, pressure sores, and leukopenia in the SG were obviously lower (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). Compared with the CG, \u201cvery satisfied\u201d and total satisfaction in the SG were obviously higher (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>&lt;<\/m:mo>\n                        <m:mn>0.05<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>). Conclusion. Application of evidence-based nursing intervention in the treatment of advanced squamous cell carcinoma of the lung by erlotinib combined with TS-1 can help patients to relieve pain, improve their psychological state, reduce the incidence of adverse reactions, significantly improve the QOL, and also enhance the satisfaction of clinical nursing.<\/jats:p>","DOI":"10.1155\/2021\/6801779","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T02:35:08Z","timestamp":1639449308000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Application of Evidence-Based Nursing Intervention in the Treatment of Advanced Squamous Cell Carcinoma of the Lung by Erlotinib Combined with Tegafur, Gimeracil, and Oteracil Potassium and Its Influence on Quality of Life"],"prefix":"10.1155","volume":"2021","author":[{"given":"Shan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nursing, Hubei Cancer Hospital, Wuhan 430079, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaocheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Hubei Cancer Hospital, Wuhan 430079, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Chest Oncology, Hubei Cancer Hospital, Wuhan 430079, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Chest Oncology, Hubei Cancer Hospital, Wuhan 430079, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9699-342X","authenticated-orcid":true,"given":"Huifen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Hubei Cancer Hospital, Wuhan 430079, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2018-0321"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2017.06.002"},{"issue":"2","key":"3","first-page":"E88","article-title":"Patient-Reported outcome data from the lux-lung 8 phase III global trial of afatinib versus erlotinib as second-line treatment for advanced squamous cell carcinoma of the lung following first-line platinum-based chemotherapy","volume":"43","author":"K Lee","year":"2016","journal-title":"Oncology Nursing Forum"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1540591"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0209"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.12218"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30717"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6118"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/bjhp.12325"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2356"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp13x674611"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4104\/pcrj.2012.00093"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.nepr.2013.01.010"},{"issue":"14","key":"14","first-page":"2537","article-title":"An analysis of the intervention effect of perioperative evidence-based nursing on orthopedic trauma patients\u2019 vagal reflex","volume":"19","author":"X.-Q. 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