{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:09:32Z","timestamp":1762474172646,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":335,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Anaplastic large\u2010cell lymphoma is a rare type of aggressive non\u2010Hodgkin\u2019s lymphoma, and arriving at a final diagnosis for this tumor is a challenge for the healthcare providers. Usually, it involves the lymph nodes and extranodal tissues such as the lungs, skin, and other soft tissues. Its presentation by extending into different organs such as the liver, lungs, bones, spleen, and thyroid is rare. Thus, involvement of other organs is very rare as we found in a 54\u2010year\u2010old male patient, a known case of hypertension and end\u2010stage renal disease who was on hemodialysis, who presented to the emergency department with a history of generalized weakness and weight loss of about 20\u2009kg for two months. The tumor cells are positive for CD45, CD30, CD15, MUMi, and Ki\u201067 (80%) and negative for CD20, PAX\u20105, CD79a, CD3, CD5, CD10, BCL6, BCL2, EMA, ALK\u20101, and CD138. The patient was hypoglycemic and hypercalcemic and was managed accordingly. The patient was evaluated, and the third assessment showed that hypoglycemia was resolved due to dexamethasone. The patient\u2019s glucose storage was depleted most likely due to liver involvement plus poor general condition. It was asserted that the patient\u2019s hypoglycemia could be related to his underlying malignancy. Also, the patient was advised to start tablet diazoxide 45\u2009mg three times a day (3\u2009mg\/kg\/day TID) in addition to levothyroxine tablet 50\u2009mcg once a day. Tablet diazoxide was stopped, and nutritional support was recommended. This case reveals a rare systematic ALK\u20101\u2010negative anaplastic large\u2010cell lymphoma that involves multiple organs. The main learning point from this report is that these tumors can present atypically even in adults and can be ALK\u20101 negative, which is contrary to the typical systematic anaplastic large\u2010cell lymphomas that are positive for ALK.<\/jats:p>","DOI":"10.1155\/2021\/6843103","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T17:50:07Z","timestamp":1638467407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rare Presentation of Hypoglycemia in a Patient with Anaplastic Large\u2010Cell Lymphoma"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9612-4072","authenticated-orcid":false,"given":"Raed","family":"Aldahash","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13521"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.04.084"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.208101"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13416"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000500259"},{"volume-title":"ALK Negative Anaplastic Large Cell Lymphoma","year":"2021","author":"Kao E. 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