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Twenty\u2010four mice were divided into four groups randomly: the CON group, ETEC group, LP\u2010ETEC group and LB\u2010ETEC group. Our results demonstrated that, compared with the ETEC group, the LP\u2010ETEC and LB\u2010ETEC groups experienced less weight loss and morphological damage of the jejunum. We measured proinflammatory factors of colonic tissue and found that <jats:italic>L. plantarum<\/jats:italic> and <jats:italic>L. brevis<\/jats:italic> inhibited the expression of proinflammatory factors such as IL\u2010<jats:italic>\u03b2<\/jats:italic>, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and IL\u20106 and promoted that of the tight junction protein such as claudin\u20101, occludin, and ZO\u20101. Additionally, <jats:italic>L. plantarum<\/jats:italic> and <jats:italic>L. brevis<\/jats:italic> altered the impact of ETEC on the intestinal microbial community of mice, significantly increased the abundance of probiotics such as <jats:italic>Lactobacillus<\/jats:italic>, and reduced that of pathogenic bacteria such as <jats:italic>Proteobacteria<\/jats:italic>, <jats:italic>Clostridia<\/jats:italic>, <jats:italic>Epsilonproteobacteria<\/jats:italic>, and <jats:italic>Helicobacter<\/jats:italic>. Therefore, we believe that <jats:italic>L. plantarum<\/jats:italic> and <jats:italic>L. brevis<\/jats:italic> can stabilize the intestinal microbiota and inhibit the growth of pathogenic bacteria, thus protecting mice from the gut inflammation induced by ETEC.<\/jats:p>","DOI":"10.1155\/2021\/6867962","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T18:09:32Z","timestamp":1632247772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["<i>Lactobacillus plantarum<\/i> and <i>Lactobacillus brevis<\/i> Alleviate Intestinal Inflammation and Microbial Disorder Induced by ETEC in a Murine 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