{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:50:59Z","timestamp":1778637059857,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T00:00:00Z","timestamp":1630195200000},"content-version":"vor","delay-in-days":240,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To investigate the expression and regulation mechanism of miR\u201029c\u20103p and cell division cycle associated 4 (CDCA4) in melanoma (MM). <jats:italic>Data and Methods<\/jats:italic>. Fifty\u2010nine patients with MM admitted to our hospital were enrolled as the MM group. They were followed up for 3 years to analyze the prognostic factors; meanwhile, 51 healthy subjects were allocated into a normal group. MM cell lines (M21 and C8161) were transfected with miR\u201029c\u20103p\u2010mimics, miR\u201029c\u20103p\u2010inhibitor, miR\u2010NC, si\u2010CDCA4, and sh\u2010CDCA4. The expression of miR\u201029c\u20103p, CDCA4, Bax, Caspase3, Bcl\u20102, N\u2010cadherin, vimentin, and E\u2010cadherin was quantified, and cell proliferation, migration, invasion, and apoptosis, as well as epithelial\u2010mesenchymal transition (EMT), were determined. <jats:italic>Results<\/jats:italic>. Serum miR\u201029c\u20103p was lowly expressed and CDCA4 was highly expressed in the MM group. The area under the curve (AUC) of both for diagnosing MM was greater than 0.9. miR\u201029c\u20103p and CDCA4 were related to regional lymph node staging (N staging), distant metastasis (M staging), tumor diameter, and pathological differentiation. Low miR\u201029c\u20103p and high CDCA4 were associated with poor prognosis of MM. Overexpression of miR\u201029c\u20103p and suppression of CDCA4 hindered cell proliferation, migration, invasion, and expression of Bax, Caspase3, N\u2010cadherin, and vimentin, but cell apoptosis and expression of Bcl\u20102 and E\u2010cadherin were enhanced. Dual\u2010luciferase reporter (DLR) assay confirmed the targeted relationship between miR\u201029c\u20103p and CDCA4. After miR\u201029c\u20103p\u2010mimics+sh\u2010CDCA4 was transfected into M21 and C8161 cells, the proliferation, invasion, and apoptosis were not different from those in the miR\u2010NC group transfected with unrelated sequences. <jats:italic>Conclusion<\/jats:italic>. Overexpression of miR\u201029c\u20103p suppresses CDCA4 expression and decreases proliferation, migration, invasion, apoptosis, and EMT of MM cells, thus hindering MM progression.<\/jats:p>","DOI":"10.1155\/2021\/7065963","type":"journal-article","created":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T18:35:09Z","timestamp":1630262109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["[Retracted] Upregulation of miR\u201029c\u20103p Hinders Melanoma Progression by Inhibiting CDCA4 Expression"],"prefix":"10.1155","volume":"2021","author":[{"given":"Jiazheng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilu","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cundi","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3896-1275","authenticated-orcid":false,"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,29]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.3"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2020.100066"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4100-0"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2305-5839.2015.12.23"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.05.005"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004396"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1586\/edm.13.15"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.10.014"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0893"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2020.140444"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-262"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.02.004"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-10-41"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.3.14056"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603800200"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5271-z"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv297"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22539-5_5"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165921"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26276"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz253"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16925-x"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165917"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165906"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.680918"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.2174\/2211536605666160901103754"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.04.023"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.11.008"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-019-01461-7"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2019.4699"},{"key":"e_1_2_7_31_2","article-title":"The anti-melanoma activity and oncogenic targets of hsa-miR-15a-5p","volume":"3","author":"Alderman C.","year":"2016","journal-title":"RNA & disease"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.86"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.08.018"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1300"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.434"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6237"}],"updated-by":[{"DOI":"10.1155\/2024\/9813483","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"record-id":"67133"},{"DOI":"10.1155\/2024\/9813483","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000}}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/7065963.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/7065963.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/7065963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T16:33:44Z","timestamp":1735662824000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/7065963"}},"subtitle":[],"editor":[{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/7065963"],"URL":"https:\/\/doi.org\/10.1155\/2021\/7065963","archive":["Portico"],"relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2024\/9813483","asserted-by":"object"}]},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7065963"}}