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It is well known that the effects of ROS on tumors are diverse, depending on ROS concentration and cell type. We found that ovarian cancer cells have significantly lower levels of ROS than normal ovarian cells. Moreover, increased ROS levels in ovarian cancer cells can substantially inhibit their migration and invasion ability. Furthermore, the results show that moderate static magnetic field (SMF) can inhibit ovarian cancer cell migration, invasion, and stemness in a ROS\u2010dependent manner. RNA sequencing results confirm that SMFs increased the oxidative stress level and reduced the stemness of ovarian cancer cells. Consistently, the expressions of stemness\u2010related genes were significantly decreased, including hyaluronan receptor (CD44), SRY\u2010box transcription factor 2 (Sox2), and cell myc proto\u2010oncogene protein (C\u2010myc). Furthermore, moderate SMFs provided by a superconducting magnet and permanent magnet have good biosafety and can both inhibit ovarian cancer metastasis in mice. Therefore, our study demonstrates the effects of SMFs on oxidative stress and metastasis in the ovarian cancer cells, which reveals the potential of applying SMF as a physical method in cancer therapy in the future.<\/jats:p>","DOI":"10.1155\/2021\/7103345","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T01:50:09Z","timestamp":1638928209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Moderate Static Magnet Fields Suppress Ovarian Cancer Metastasis via ROS\u2010Mediated Oxidative 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