{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:19:46Z","timestamp":1773332386220,"version":"3.50.1"},"reference-count":86,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Neurology"],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:p>Major depressive disorder (MDD) still has an unknown etiology and mechanisms. Many studies have been conducted seeking to associate and understand the connection of different genetic variants to this disease. Researchers have extensively studied the brain-derived neurotrophic factor (BDNF) Val66Met genetic variant in MDD; yet, their findings remain inconsistent. This systematic review sought to verify the GG (Val\/Val) genotype frequency fluctuation in different populations with MDD. For this, we searched in different databases and, after applying the eligibility criteria, selected 17 articles. Most studies demonstrate the higher frequency of the ancestral (wild) GG (Val\/Val) genotype, although associations of the polymorphic A (Met) allele, changes in BDNF protein serum levels, or both were also found in MDD, whether related to the disease\u2019s development or other factors. Nevertheless, despite these findings, disagreements between several studies are seen. For this reason, further BDNF Val66Met genetic variant studies should not only bridge the gap in the knowledge of this polymorphism\u2019s role in MDD\u2019s different facets but also analyze the genotypic and phenotypic heterogeneity in different populations to help provide a better quality of life for patients.<\/jats:p>","DOI":"10.1155\/2021\/7117613","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T17:35:13Z","timestamp":1635788113000},"page":"1-16","source":"Crossref","is-referenced-by-count":7,"title":["BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder"],"prefix":"10.1155","volume":"2021","author":[{"given":"Caroline","family":"Ferreira Fratelli","sequence":"first","affiliation":[{"name":"Health Sciences and Technologies Program, University of Brasilia, Faculty of Ceil\u00e2ndia, Brasilia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jhon","family":"Willatan Siqueira","sequence":"additional","affiliation":[{"name":"University of Brasilia, Faculty of Ceil\u00e2ndia, Brasilia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna","family":"Rodrigues Gontijo","sequence":"additional","affiliation":[{"name":"Health Sciences and Technologies Program, University of Brasilia, Faculty of Ceil\u00e2ndia, Brasilia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio","family":"de Lima Santos","sequence":"additional","affiliation":[{"name":"University of Brasilia, Faculty of Ceil\u00e2ndia, Brasilia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calliandra Maria","family":"de Souza Silva","sequence":"additional","affiliation":[{"name":"University of Brasilia, Faculty of Ceil\u00e2ndia, Brasilia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6836-3583","authenticated-orcid":true,"given":"Izabel Cristina","family":"Rodrigues da Silva","sequence":"additional","affiliation":[{"name":"University of Brasilia, Faculty of Ceil\u00e2ndia, Brasilia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","volume-title":"Mental Health Atlas","author":"World Health Organization","year":"2017"},{"key":"2","article-title":"Transtornos depressivos","volume-title":"Manual Diagn\u00f3stico e Estat\u00edstico de Transtornos Mentais: DSM-5.5","author":"American Psychiatric Association","year":"2014"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1802331115"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-020-01508-6"},{"key":"5","volume-title":"Depression in children","author":"A. 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