{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T10:40:17Z","timestamp":1786790417183,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1A5A2015805"],"award-info":[{"award-number":["NRF-2017R1A5A2015805"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1I1A3A01062432"],"award-info":[{"award-number":["2019R1I1A3A01062432"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,5,28]]},"abstract":"<jats:p>Joa-gui em (\u5de6\u6b78\u98ee, JGE) is known to be effective for treating kidney-yin deficient syndrome. However, there is a lack of objective pharmacological research on improving kidney function. This study was designed to evaluate whether JGE improves renal function and related mechanisms in rats with acute renal injury induced by ischemia\/reperfusion (I\/R). The acute renal failure (ARF) group was subjected to reperfusion after inserting a clip into the renal artery for 45\u2009min. The ARF\u2009+\u2009JGE (100 or 200\u2009mg\/kg\/day) groups were orally administered for four days after their I\/R surgery, respectively. JGE treatment suppressed the increase in kidney size in the ARF animal model and alleviated the polyuria symptoms. In addition, to confirm the effect of improving the kidney function of JGE, lactate dehydrogenase levels, blood urea nitrogen\/creatinine ratio, and creatinine clearance were measured. As a result, it decreased in the ARF group but significantly improved in the JGE group. Also, as a result of examining the morphological aspects of renal tissue, it was shown that JGE improved renal fibrosis caused by ARF. Meanwhile, it was confirmed that JGE reduced inflammation through the nucleotide-binding oligomerization domain-like receptor pyrin domain containing-3 (NLRP3) and toll-like receptor 4 (TLR4)\/nuclear factor kappa B (NF-\u03baB) signaling pathways, which are the major causes of acute ischemic kidney injury, thereby improving renal function disorder. The JGE has a protective effect by improving the NLRP3 and TLR4\/NF-\u03baB signaling pathway in rats with acute renal dysfunction induced by I\/R injury.<\/jats:p>","DOI":"10.1155\/2021\/7178868","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T23:53:09Z","timestamp":1622245989000},"page":"1-10","source":"Crossref","is-referenced-by-count":4,"title":["Protective Effect of Joa-Gui Em through the Improvement of the NLRP3 and TLR4\/NF-\u03bab Signaling by Ischemia\/Reperfusion-Induced Acute Renal Failure Rats"],"prefix":"10.1155","volume":"2021","author":[{"given":"Se Won","family":"Na","sequence":"first","affiliation":[{"name":"College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"},{"name":"Hanbang Cardio-Renal Research Center and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Jae","family":"Jang","sequence":"additional","affiliation":[{"name":"College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"},{"name":"Hanbang Cardio-Renal Research Center and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Hyeon","family":"Hong","sequence":"additional","affiliation":[{"name":"College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"},{"name":"Hanbang Cardio-Renal Research Center and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Joo","family":"Yoon","sequence":"additional","affiliation":[{"name":"College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"},{"name":"Hanbang Cardio-Renal Research Center and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Sub","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"},{"name":"Hanbang Cardio-Renal Research Center and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0396-0862","authenticated-orcid":true,"given":"Hye Yoom","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"},{"name":"Hanbang Cardio-Renal Research Center and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9952-9697","authenticated-orcid":true,"given":"Dae Gill","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"},{"name":"Hanbang Cardio-Renal Research Center and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4755-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s1734-1140(12)70728-4"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/mnh.0000000000000605"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c110041"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00431.2011"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.16"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2010020143"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.03.003"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2015.01.010"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2010080798"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.06.017"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201959"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000033611.79556.ae"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0110-2"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.07.014"},{"issue":"1","key":"17","first-page":"101","article-title":"Bibliographical studies on the effect of \u201cjoa-gui em\u201d (\u5de6\u6b78\u98ee)","volume":"14","author":"J. K. Choi","year":"2005","journal-title":"Journal of Haehwa Medicine"},{"issue":"1","key":"18","first-page":"62","article-title":"Effects of Jwagyuyeum and Woogyuyeum on free radical generating enzyme activities and lipid peroxidation in senile rat\u2019s liver","volume":"16","author":"C. H. Yoon","year":"1995","journal-title":"The Korean Journal of Internal Medicine"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-019-01285-1"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.nephro.2018.11.002"},{"key":"21","first-page":"378","article-title":"Glomerular alterations in an ischemic model of acute renal failure","volume":"45","author":"J. L. Barnes","year":"1981","journal-title":"Laboratory Investigation; a Journal of Technical Methods and Pathology"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00644.x"},{"issue":"4","key":"23","first-page":"21","article-title":"The role of medications and their management in acute kidney injury","volume":"18","author":"B. L. McDaniel","year":"2015","journal-title":"Integrated Pharmacy Research and Practice"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.08.044"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x11009287"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00394-7"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1042\/bc20040148"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1159\/000494807"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.2174\/1871527315666160321111829"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.982777"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.5414\/cn106921"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1761-4"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00564-2015"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1703"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.212"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00461"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00883"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2017.05.028"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.11.026"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-8871-2_16"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/7178868.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/7178868.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/7178868.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T23:53:14Z","timestamp":1622245994000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/7178868\/"}},"subtitle":[],"editor":[{"given":"Baotong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,5,28]]},"references-count":40,"alternative-id":["7178868","7178868"],"URL":"https:\/\/doi.org\/10.1155\/2021\/7178868","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5,28]]}}}