{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:36:22Z","timestamp":1772231782592,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2021,9,9]]},"abstract":"<jats:p>Introduction. Gastrointestinal angiosarcomas are rare and represent less than 1% of all gastrointestinal tract malignancies, with most occurring in the stomach and small intestine. Occurrence in the colorectal segments is considered extremely rare. Case Report. We describe the case of a 61-year-old male with multiple primary angiosarcomas of the colon who presented with fever and abdominal pain. The patient was initially hospitalized and treated as having an infectious disease. A multislice computed tomography (MSCT) scan revealed multiple soft tissue tumors in the region of the left iliopsoas and gluteus medius muscles. After developing hematochezia, a colonoscopy was performed which found an ulcerated tumor in the sigmoid colon. The small tissue biopsy taken during the procedure presented diagnostic difficulties and was given a preliminary diagnosis of gastrointestinal stromal tumor (GIST). Examination of the resected colon segment and surrounding fat tissue revealed four separate tumors. Microscopically, the tumors were composed of solid sheets of spindle and epithelioid neoplastic cells with prominent nucleoli and numerous mitotic figures and immunohistochemically positive for ERG, CD31, CD34, vimentin, and CD117, while negative for CK7, CK20, CD20, CD3, CD45, TTF-1, PAN-CK, ALK, Mpox, S-100, and DOG1, leading to the final diagnosis of multiple colonic angiosarcomas. The patient\u2019s condition declined rapidly and he passed away from multiple organ failures 60 days after initial hospitalization. Conclusion. Both clinical and pathological diagnoses of colorectal angiosarcoma are challenging. Patients are present with nonspecific symptoms leading to mismanagement and late diagnosis. A definitive pathological diagnosis relies on immunohistochemical staining for endothelial markers. Misdiagnosis as poorly differentiated adenocarcinoma or GIST is possible in limited tissue biopsies.<\/jats:p>","DOI":"10.1155\/2021\/7237379","type":"journal-article","created":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T17:20:07Z","timestamp":1631380807000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Multiple Primary Angiosarcomas of the Colon"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-0634","authenticated-orcid":true,"given":"Sonja","family":"Radi\u0107","sequence":"first","affiliation":[{"name":"Department of Pathology and Cytology, General Hospital Karlovac, Karlovac, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Zovak","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Galovi\u0107 Mari\u0107","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stjepan","family":"Baturina","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica Stephany","family":"Kirigin","sequence":"additional","affiliation":[{"name":"Ljudevit Jurak Department of Pathology and Cytology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u017eo","family":"Kru\u0161lin","sequence":"additional","affiliation":[{"name":"Ljudevit Jurak Department of Pathology and Cytology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0698-5"},{"key":"2","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1308\/147870811X591017","article-title":"Angiosarcoma of sigmoid colon with intraperitoneal bleeding: case report and literature review","volume":"93","author":"T. 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