{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:22:30Z","timestamp":1767165750192,"version":"build-2238731810"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":277,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . B.1.617.1, a variant of severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) causing respiratory illness is responsible for the second wave of COVID\u201019 and associated with a high incidence of infectivity and mortality. To mitigate the B.1.617.1 variant of SARS\u2010CoV\u20102, deciphering the protein structure and immunological responses by employing bioinformatics tools for data mining and analysis is pivotal.\n                    <jats:italic>Objectives<\/jats:italic>\n                    . Here, an in silico approach was employed for deciphering the structure and immune function of the subunit of spike (S) protein of SARS\u2010CoV\u20102 B.1.617.1 variant.\n                    <jats:italic>Methods<\/jats:italic>\n                    . The partial amino acid sequence of SARS\u2010CoV\u20102 B.1.617.1 variant S protein was analyzed, and its putative secondary and tertiary structure was predicted. Immunogenic analyses including B\u2010 and T\u2010cell epitopes, interferon\u2010gamma (IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    ) response, chemokine, and protective antigens for SARS\u2010CoV 2 S proteins were predicted using appropriate tools.\n                    <jats:italic>Results<\/jats:italic>\n                    . B.1.617.1 variant S protein sequence was found to be highly stable and amphipathic. ABCpred and CTLpred analyses led to the identification of two potential antigenic B cell and T cell epitopes with starting amino acid positions at 60 and 82 (for B cell epitopes) and 54 and 98 (for T cell epitopes) having prediction scores &gt; 0.8. Further, RAMPAGE tool was used for determining the allowed and disallowed regions of the three\u2010dimensional predicted structure of SARS\u2010CoV\u20102 B.1.617.1 variant S protein.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Together, the in silico analysis revealed the predicted structure of partial S protein, immunogenic properties, and possible regions for S protein of SARS\u2010CoV\u20102 and provides a valuable prelude for engineering the targeted vaccine or drug against B.1.617.1 variant of SARS\u2010CoV\u20102.\n                  <\/jats:p>","DOI":"10.1155\/2021\/7251119","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T12:38:51Z","timestamp":1633437531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["[Retracted] A Bioinformatics Approach for the Prediction of Immunogenic Properties and Structure of the SARS\u2010COV\u20102 B.1.617.1 Variant Spike Protein"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0320-6640","authenticated-orcid":false,"given":"Vijay Kumar","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0386-881X","authenticated-orcid":false,"given":"Sanket","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0638-9777","authenticated-orcid":false,"given":"Gazal","family":"Bhargava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-6636","authenticated-orcid":false,"given":"Ajay","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7555-4292","authenticated-orcid":false,"given":"Juhi","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4135-7466","authenticated-orcid":false,"given":"Anupam","family":"Jyoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385885-6.00009-2"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.03.003"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0118-9"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14630-2"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211721"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25678"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2020.01.004"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30154-9"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/v12040360"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2507"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.03.002"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1760137"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2179-y"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116480"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00127-20"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-890-0:571"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21078"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzp016"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-8-4"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6150-8-30"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks400"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-00679-1"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm404"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.3"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889892009944"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/4.2.155"},{"key":"e_1_2_9_29_2","first-page":"1895","article-title":"Thermostability and aliphatic index of globular proteins","volume":"88","author":"Ikai A.","year":"1980","journal-title":"The Journal of Biochemistry"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00304-08"},{"key":"e_1_2_9_31_2","unstructured":"EdaraV. 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