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However, it remains unsatisfactory for its intervention by using pharmacological strategies. Oxidative stress is a main pharmacological process involved in SCI\/R, which will elicit downstream programmed cell death such as the novel defined necroptosis. Astragalin is a bioactive natural flavonoid with a wide spectrum of pharmacological activities. Herein, we firstly evaluated the effect of astragalin to oxidative stress as well as the possible downstream necroptosis after SCI\/R in mice. Our results demonstrated that astragalin improves the ethological score and histopathological deterioration of SCI\/R mice. Astragalin mitigates oxidative stress and ameliorates inflammation after SCI\/R. Astragalin blocks necroptosis induced by SCI\/R. That is, the amelioration of astragalin to the motoneuron injury and histopathological changes. Indicators of oxidative stress, inflammation, and necroptosis after SCI\/R were significantly blocked. Summarily, we firstly illustrated the protection of astragalin against SCI\/R through its blockage to the necroptosis at downstream of oxidative stress.<\/jats:p>","DOI":"10.1155\/2021\/7254708","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T20:20:11Z","timestamp":1635452411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["[Retracted] Astragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress\u2010Induced 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