{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:58:31Z","timestamp":1772661511582,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Safe Surgery in War Zone DRC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Otolaryngology"],"published-print":{"date-parts":[[2021,10,25]]},"abstract":"<jats:p>Background. Holoprosencephaly (HPE) is a rare cerebrofacial abnormality resulting from the complete or partial failure of the diverticulation and cleavage of the primitive forebrain. It has an incidence at birth of 1:16000. Case Presentation. We report a case of a 2600\u2009g newborn female delivered by an HIV-infected mother in whom an antenatal ultrasound scan at 34 weeks\u2019 gestation reported features of fetal alobar holoprosencephaly. The neonate was born with cebocephaly, a monkey-like head, and did not survive for more than 30 minutes following delivery by caesarian section despite oxygen therapy. Conclusion. Alobar HPE with cebocephaly remains incompatible with life. In this resource-limited setting, the diagnosis was made clinically, and only an ultrasound scan was performed to confirm the diagnosis. Chromosomal analysis could have given more information.<\/jats:p>","DOI":"10.1155\/2021\/7282283","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T17:50:07Z","timestamp":1635184207000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["Alobar Holoprosencephaly with Cebocephaly in a Neonate Born to an HIV-Positive Mother in Eastern Uganda"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8101-273X","authenticated-orcid":true,"given":"Franck Katembo","family":"Sikakulya","sequence":"first","affiliation":[{"name":"Faculty of Clinical Medicine and Dentistry, Department of Surgery, Kampala International University Western Campus, Ishaka-Bushenyi, Kampala, Uganda"},{"name":"Faculty of Medicine, Universit\u00e9 Catholique du Graben, Butembo, Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonye Magugu","family":"Kiyaka","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Medicine and Dentistry, Department of Surgery, Kampala International University Western Campus, Ishaka-Bushenyi, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Masereka","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Medicine and Dentistry, Department of Surgery, Kampala International University Western Campus, Ishaka-Bushenyi, Kampala, Uganda"},{"name":"Department of Surgery, Jinja Regional Referral Hospital, Jinja, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2053-1696","authenticated-orcid":true,"given":"Robinson","family":"Ssebuufu","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Medicine and Dentistry, Department of Surgery, Kampala International University Western Campus, Ishaka-Bushenyi, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.151.2.6709918"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1976.02120090074014"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-3-35"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320280110"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(83)80185-1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30247"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-8"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.8.1.3281191"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.28.12.846"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1148\/rg.351140040"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1159\/000104278"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0223(199804)18:4<393::aid-pd277>3.0.co;2-q"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/pd.552"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2233011197"}],"container-title":["Case Reports in Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criot\/2021\/7282283.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criot\/2021\/7282283.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criot\/2021\/7282283.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T17:50:11Z","timestamp":1635184211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/criot\/2021\/7282283\/"}},"subtitle":[],"editor":[{"given":"Abr o","family":"Rapoport","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,25]]},"references-count":14,"alternative-id":["7282283","7282283"],"URL":"https:\/\/doi.org\/10.1155\/2021\/7282283","relation":{},"ISSN":["2090-6773","2090-6765"],"issn-type":[{"value":"2090-6773","type":"electronic"},{"value":"2090-6765","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10,25]]}}}