{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:18:09Z","timestamp":1740140289866,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971049","2015CB554402","2015CB554405"],"award-info":[{"award-number":["31971049","2015CB554402","2015CB554405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["31971049","2015CB554402","2015CB554405"],"award-info":[{"award-number":["31971049","2015CB554402","2015CB554405"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,9,16]]},"abstract":"<jats:p>Depressive symptoms have been found to be highly prevalent among patients with coronary heart disease (CHD) and seriously affect the patients\u2019 quality of life. However, most psychotropic drugs have warnings about potential side effects. Accordingly, safer effective alternatives are urgently demanded. Angina pectoris of CHD is considered as \u201cchest stuffiness and heartache syndrome\u201d in traditional Chinese medicine, with the major syndrome type named Qi stagnation and blood stasis. Qi-regulating and blood circulation-promoting therapy has increasingly shown unique advantages in CHD patients. This study investigated the efficacy of Xuefu Zhuyu decoction, a representative prescription of Qi-regulating and blood circulation-promoting therapy, on angina pectoris patients with depressive symptoms. Depressive symptoms were stratified at baseline in 30 patients with stable angina pectoris who participated in both baseline and 12-week follow-up studies. After performing a stratified analysis, the angina pectoris-specific health status and traditional Chinese medicine \u201cchest stuffiness and heartache syndrome\u201d were evaluated by self-reports using the associated questionnaire scales, respectively. We measured serum concentrations of serotonin, brain-derived neurotrophic factor, and ATP, which are associated with the development of depression. We found that the Xuefu Zhuyu granule significantly improved the angina pectoris-specific health status in patients after 12 weeks of treatment; specifically, it had a better curative effect on patients with depressive symptoms. Xuefu Zhuyu granule also significantly improved the chest stuffiness and heartache syndrome in patients with depressive symptoms (efficacy index is 61.24%, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> versus baseline). Interestingly, Xuefu Zhuyu granule has been found to be more susceptible to improving ATP levels in patients with depressive symptoms, indicating that the improvement in serum ATP levels might account for the better efficacy of Xuefu Zhuyu granule in patients with depressive symptoms. Our data provide prospective evidence that Xuefu Zhuyu granule improves angina pectoris-specific health status through regulating Qi and promoting blood circulation. This trial is registered with ChiCTR-IOR-15006989.<\/jats:p>","DOI":"10.1155\/2021\/7319417","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T20:50:06Z","timestamp":1631825406000},"page":"1-12","source":"Crossref","is-referenced-by-count":5,"title":["Qi-Regulating and Blood Circulation-Promoting Therapy Improves Health Status of Stable Angina Pectoris Patients with Depressive Symptoms"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-2762","authenticated-orcid":true,"given":"Xiao-Reng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, PLA General Hospital, Beijing 100853, China"},{"name":"Laboratory of Radiation Injury Treatment, Medical Innovation Research Division, PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan-Dan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-Qi","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Dong","family":"Wu","sequence":"additional","affiliation":[{"name":"Cadre Medical Department, The 1st Medical Center, PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8742-9552","authenticated-orcid":true,"given":"Xue-Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Cadre Medical Department, The 1st Medical Center, PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8640-4732","authenticated-orcid":true,"given":"Xiu-Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2009.10.002"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002902.pub4"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.07.003"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl338"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000019"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.17.1878"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.6.701"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.03.026"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3106"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.4.367"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/fjc.0b013e3182677041"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2010.02.010"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/s0033-3182(85)72774-0"},{"issue":"7","key":"14","first-page":"647","article-title":"Difficulties and countermeasures in research for prevention and treatment of coronary heart disease by integrative Chinese and Western medicine","volume":"27","author":"H. 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