{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:21:24Z","timestamp":1790112084737,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":339,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["cstc2021jcyj-msxmX0070"],"award-info":[{"award-number":["cstc2021jcyj-msxmX0070"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","award":["KJZD-K202001602"],"award-info":[{"award-number":["KJZD-K202001602"]}],"id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Lactobacillus plantarum<\/jats:italic> ZS62 is a newly isolated strain from naturally fermented yogurt that might offer some beneficial effects in the setting of alcohol\u2010induced subacute liver injury. The liver\u2010protective effect of <jats:italic>L. plantarum<\/jats:italic> ZS62 was investigated by gavage feeding of mice with this <jats:italic>Lactobacillus<\/jats:italic> strain (1 \u00d7 10<jats:sup>9<\/jats:sup> CFU\/kg <jats:sub>BW<\/jats:sub>) before alcohol administration daily for 7 days. We then compared hepatic morphology, liver function indexes, liver lipid levels, inflammation, oxidative stress levels, and mRNA expression of oxidative metabolism\u2010 and inflammation\u2010related genes in mice that had been pretreated with <jats:italic>Lactobacillus plantarum<\/jats:italic> versus control mice that had not been pretreated. Our results showed that <jats:italic>L. plantarum<\/jats:italic> ZS62 attenuated alcohol\u2010induced weight loss; prevented morphological changes in hepatocytes; reduced markers of liver damage including aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), hyaluronidase (HAase), precollagen III (PC III), and inflammatory cytokines; and enhanced the antioxidative status. <jats:italic>L. plantarum<\/jats:italic> ZS62 also significantly downregulated inflammation\u2010related genes and upregulated lipid\u2010 and oxidative\u2010metabolism genes. Thus, <jats:italic>Lactobacillus plantarum<\/jats:italic> pretreatment appears to confer hepatic protection by reducing inflammation and enhancing antioxidative capacity. The protective effect of <jats:italic>L. plantarum<\/jats:italic> ZS62 was even better than that of a commonly used commercial lactic acid bacteria (<jats:italic>Lactobacillus delbrueckii<\/jats:italic> subsp. <jats:italic>Bulgaricus<\/jats:italic>). The <jats:italic>L. plantarum<\/jats:italic> ZS62 might be a potentially beneficial prophylactic treatment for people who frequently drink alcoholic beverages.<\/jats:p>","DOI":"10.1155\/2021\/7337988","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T23:20:12Z","timestamp":1638832812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Antioxidative and Anti\u2010Inflammatory Effects of <i>Lactobacillus plantarum<\/i> ZS62 on Alcohol\u2010Induced Subacute Hepatic Damage"],"prefix":"10.1155","volume":"2021","author":[{"given":"Yi","family":"Gan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruokun","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-7865","authenticated-orcid":false,"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.3920\/BM2014.0063"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-020-09704-0"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO01939A"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2019.33933.8073"},{"key":"e_1_2_11_5_2","article-title":"The potential of probiotics in the prevention and treatment of atherosclerosis","volume":"64","author":"O\u2019Morain V. 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