{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:03:01Z","timestamp":1790960581343,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1I1A2A01063598"],"award-info":[{"award-number":["NRF-2019R1I1A2A01063598"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,1,6]]},"abstract":"<jats:p>Localized adiposity is not only a common aesthetic issue but also a health risk factor. Pharmacopuncture can be a therapeutic option for the imbalance of regional fat distribution. The tuber of Pinellia ternata has been prescribed as antitussive and expectorant as a traditional Korean medicine. This study investigated the effects of pharmacopuncture with P. ternata water extract (PT) on localized adiposity. Male C57BL\/6J mice were fed on a high-fat diet (HFD) for 6 weeks. 100\u2009\u03bcL of 10\u2009mg\/mL of PT was injected into the left-side inguinal fat pad, while saline was injected into the right-side inguinal fat pad as self-control. Treatments were performed 3 times per week for 4 weeks. The inguinal fat weight was analyzed by dual-energy X-ray absorptiometry. PT pharmacopuncture significantly decreased the weight of the inguinal fat pad. The adipocyte size was reduced with increases of lipolytic enzymes and lipophagy-related factors by PT pharmacopuncture. There was marked inhibition of lipid accumulation content in 3T3-L1 adipocytes by PT treatment. The expressions of adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), autophagy-related gene (ATG) 5, ATG7, and LC3 were markedly increased by PT treatments in vivo and in vitro. This study suggests that pharmacopuncture of Pinellia ternata has ameliorative effects on adiposity by lipid catabolic effects via activating both lipolysis and lipophagy in a localized region.<\/jats:p>","DOI":"10.1155\/2021\/7347639","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:50:34Z","timestamp":1609980634000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Lipolytic and Lipophagic Effects of Pinellia ternata Pharmacopuncture on Localized Adiposity"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2750-8811","authenticated-orcid":true,"given":"Haesu","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Convergence Korean Medical Science, College of Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-5441","authenticated-orcid":true,"given":"Mi Hye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Convergence Korean Medical Science, College of Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-8813","authenticated-orcid":true,"given":"Seong Chul","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Convergence Korean Medical Science, College of Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0887-738X","authenticated-orcid":true,"given":"Jae Min","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Convergence Korean Medical Science, College of Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9254-0466","authenticated-orcid":true,"given":"Jun Hyuk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Convergence Korean Medical Science, College of Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-2386","authenticated-orcid":true,"given":"Woong Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Convergence Korean Medical Science, College of Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1159\/000471488"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1100747"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.3.379"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0535"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/dss.0000000000000209"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2010.11.018"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1177\/1090820x10362728"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/00042728-200702000-00007"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2005.00211.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2006.08.006"},{"key":"11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3831\/KPI.2016.19.010","article-title":"History of research on pharmacopuncture in Korea","volume":"19","author":"K.-H. 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