{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:00:41Z","timestamp":1790125241229,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010104","name":"Tianjin Medical University","doi-asserted-by":"publisher","award":["1913"],"award-info":[{"award-number":["1913"]}],"id":[{"id":"10.13039\/501100010104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,9,22]]},"abstract":"<jats:p>Background. Cancer has been considered as the leading cause of death in the world. In patients with cancer, up to 80% display a cachectic period after diagnosis. Cachexia is known to have a negative impact on function, treatment tolerance, higher rates of hospitalizations, and mortality. Anorexia is often used as a warning sign of precachexia. Long-term anorexia may lead to malnutrition and, then, accelerate the occurrence of cachexia. A safe and effective treatment, which can both improve appetite and assist nutritional support for precachexia cancer patients shows its particular important role. Methods. A retrospective analysis comparing the different therapeutic effects on precachexia cancer patients with anorexia-malnutrition. We recorded 46 patients with the improved-Sijunzi decoction combined with enteral nutrition emulsion (ISJZ group) and 35 patients with single enteral nutrition emulsion (SEN group). The different therapeutic effects of the two groups were observed by recording indicators before and 2 weeks after treatment, including patient-generated subjective global assessment score, quality of life score, Karnofsky performance status scale, Eastern cooperative oncology group scale standard and traditional Chinese medicine syndrome, daily total dietary intake, red blood cells, hemoglobin, prealbumin, albumin, total protein cholinesterase, C-reactive protein, leukocytes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, urea nitrogen, and creatinine. Results. ISJZ group exhibited prominent improvement of traditional Chinese medicine syndrome (TCMS), nutritional condition, and quality of life compared with the SEN group (QOL: <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.0001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, PG-SGA: <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.019<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, dietary intake: <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.0001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, TCMS: <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.0001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). The levels of HGB (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.006<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>), PAlb (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.001<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>), Alb (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.0001<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>), TP (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>p<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.008<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>), and ChE (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>p<\/q:mi>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>0.0001<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>) in the ISJZ group were higher than the SEN group after treatment. Moreover, the ratios of CRP\/ALB (<jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>p<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.028<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>) and CRP\/PALB (<jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>p<\/u:mi>\n                        <u:mo>=<\/u:mo>\n                        <u:mn>0.005<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>) in the two groups have obvious differences; they were lower for the ISJZ group than the SEN group. Conclusions. Enteral nutrition combined with ISJZ decoction is an effective treatment in precachexia cancer patients for the prevention of cachexia. This treatment therapy can alleviate the inflammatory response, improve malnutrition state, and promote the performance status. Tianjin Medical University Cancer Institute and Hospital approved this study (Trial No. 1913).<\/jats:p>","DOI":"10.1155\/2021\/7357521","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T20:17:27Z","timestamp":1632514647000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["Enteral Nutrition Combined with Improved-Sijunzi Decoction Shows Positive Effect in Precachexia Cancer Patients: A Retrospective Analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-1309","authenticated-orcid":true,"given":"Yueying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nutrition Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China"},{"name":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, China"},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Huanhu West Road, Hexi District, Tianjin 300060, China"},{"name":"Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Changling Road, Liqizhuang Street, Xiqing District, Tianjin 300380, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nutrition Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China"},{"name":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, China"},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Huanhu West Road, Hexi District, Tianjin 300060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Nutrition Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China"},{"name":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, China"},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Huanhu West Road, Hexi District, Tianjin 300060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Nutrition Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China"},{"name":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, China"},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Huanhu West Road, Hexi District, Tianjin 300060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China"},{"name":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, China"},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Huanhu West Road, Hexi District, Tianjin 300060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Changling Road, Liqizhuang Street, Xiqing District, Tianjin 300380, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, Taipa 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7707-4639","authenticated-orcid":true,"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China"},{"name":"Key Laboratory of Cancer Prevention and Therapy, Tianjin, China"},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Huanhu West Road, Hexi District, Tianjin 300060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2011.0086"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju129"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2304-8"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.52.2.72"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(10)70218-7"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5542"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2018.08.04"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-013-0105-y"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2018.05.08"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.07.015"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0132"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd004310.pub3"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2021.1873954"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz155.263"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-15-272"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-012-0960-y"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.12.035"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9012929"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.08.021"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.5560"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v8.i5.792"},{"key":"24","first-page":"241","article-title":"Anti-tumor and immune-modulating effect of Jiawei Sijunzi decoction in mice bearing hepatoma H22 tumor","volume":"39","author":"L. Chen","year":"2019","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000016950"},{"issue":"2","key":"26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s13539-011-0027-5","article-title":"The cachexia score (CASCO): a new tool for staging cachectic cancer patients","volume":"2","author":"M. A. Josep","year":"2011","journal-title":"Journal of Cachexia Sarcopenia Muscle"},{"issue":"15","key":"27","first-page":"13","article-title":"Investigation and analysis of factors influencing quality of life in elderly patients with digestive tract cancer during chemotherapy","volume":"16","author":"M. L. Xu","year":"2019","journal-title":"Nursing Practice and Research"},{"key":"28","volume-title":"Chinese Criteria for Diagnosis and Efficacy of Disease","author":"Chinese Medicine Disease Diagnosis and Curative Effect Standard Editorial Committee","year":"1994"},{"key":"29","volume-title":"Guidelines for Clinical Research of New Chinese Medicines","author":"X. Y. Zheng","year":"2002"},{"key":"30","first-page":"154","article-title":"Cancer anorexia-cachexia syndrome","volume":"44","author":"Y. Muliawati","year":"2012","journal-title":"Acta medica Indonesiana"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0112"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn452"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.s211363"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-018-0892-0"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2013.35281"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.33160\/yam.2020.02.002"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13217"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2018.07.002"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/65.1.25"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.06.866"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v9.i7.140"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/7357521.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/7357521.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/7357521.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T20:17:53Z","timestamp":1632514673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/7357521\/"}},"subtitle":[],"editor":[{"given":"Yoshiki","family":"Mukudai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,22]]},"references-count":41,"alternative-id":["7357521","7357521"],"URL":"https:\/\/doi.org\/10.1155\/2021\/7357521","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,22]]}}}