{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:15:35Z","timestamp":1767168935110,"version":"build-2238731810"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":329,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Karamay City Innovative Talent Project","award":["2018RC001A-01"],"award-info":[{"award-number":["2018RC001A-01"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . In this study, we explored the influence of single nucleotide polymorphism (SNP) in the noncoding region of intercellular adhesion molecule 1 (ICAM1) gene on the occurrence and metastasis of primary hepatocellular carcinoma (PHC).\n                    <jats:italic>Methods<\/jats:italic>\n                    . Sanger sequencing was used to analyze the genotypes of rs3093032, rs923366, and rs281437 locus in the 3\u2009\n                    <jats:sup>\u2032<\/jats:sup>\n                    untranslated region (UTR) of the\n                    <jats:italic>ICAM1<\/jats:italic>\n                    gene. The level of plasma ICAM1 was analyzed by enzyme\u2010linked immunosorbent assay (ELISA).\n                    <jats:italic>Results<\/jats:italic>\n                    . After adjusting for risk factors such as BMI, smoking, drinking, family history of tumors, and hepatitis B virus test results, the CT genotype at rs3093032 of the\n                    <jats:italic>ICAM1<\/jats:italic>\n                    gene (OR = 0.19, 95% CI: 0.08\u20100.44,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01), dominance model (OR = 0.23, 95% CI: 0.11\u20100.48,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01), and T allele (OR = 0.27, 95% CI: 0.14\u20100.53,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01) were related to the reduced risk of PHC susceptibility. rs923366 locus CT genotype (OR = 0.63, 95% CI: 0.44\u20100.90,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.01), TT genotype (OR = 0.23, 95% CI: 0.10\u20100.53,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01), dominant model (OR = 0.55, 95% CI: 0.39\u20100.77,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01), recessive model (OR = 0.28, 95% CI: 0.12\u20100.62,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01), and T allele (OR = 0.55, 95% CI: 0.42\u20100.73,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01) were related to a reduction in the risk of PHC susceptibility. rs281437 locus CT genotype (OR = 2.08, 95% CI: 1.40\u20103.09,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01), TT genotype (OR = 5.20, 95% CI: 2.22\u201012.17,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01), dominant model (OR = 2.45, 95% CI: 1.69\u20103.54,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01), recessive model (OR = 4.32, 95% CI: 1.86\u201010.06,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01), and T allele (OR = 2.46, 95% CI: 1.79\u20103.38,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01) were significantly related to the increased risk of PHC susceptibility. SNPs at rs3093032, rs923366, and rs281437 of the\n                    <jats:italic>ICAM1<\/jats:italic>\n                    gene were significantly correlated with TNM stage and tumor metastasis of PHC patients (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . SNPs at rs3093032, rs923366, and rs281437 in the 3\u2009\n                    <jats:sup>\u2032<\/jats:sup>\n                    UTR region of the\n                    <jats:italic>ICAM1<\/jats:italic>\n                    gene are related to the occurrence and metastasis of PHC.\n                  <\/jats:p>","DOI":"10.1155\/2021\/7377299","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T16:20:07Z","timestamp":1637943607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["[Retracted] The Influence of ICAM1 3\u2032UTR Gene Polymorphism on the Occurrence and Metastasis of Primary Liver 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