{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:42:46Z","timestamp":1793119366073,"version":"4.5.0"},"reference-count":73,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":130,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Dyslipidemia is one of the leading causes of cardiovascular complications in diabetes mellitus (DM) patients. Though it is a major public health problem in Ethiopia, there is no a nation\u2010wide study to determine dyslipidemia among DM patients yet. Therefore, this systematic review and meta\u2010analysis intended to estimate the prevalence of hypertriglyceridemia and other plasma lipid abnormalities among people living with DM in Ethiopia. <jats:italic>Methods<\/jats:italic>. We systematically searched PubMed, Google Scholar, African Journals Online, Hinari, and direct Google. Studies conducted until May 9, 2020, that reports the prevalence of dyslipidemia among people living with DM were included. The DerSimonian and Laird random\u2010effects model was used to determine the pooled prevalence of lipid profile abnormalities. Heterogeneity was checked using the <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistic, whereas publication bias was tested by funnel plot and Egger\u2019s test. Besides, subgroup and sensitivity analyses were performed. <jats:italic>Results<\/jats:italic>. We used 18 primary studies, including 4961 participants living with DM, which met the eligibility criteria for the meta\u2010analysis of hypertriglyceridemia. The estimate of hypertriglyceridemia (\u2265150\u2009mg\/dl) was 48.15% (95% CI: 38.15\u201058.15, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 98.4<jats:italic>%<\/jats:italic>) after performing the main meta\u2010analysis using the random\u2010effects model. The subgroup analysis showed a higher pooled estimate of hypertriglyceridemia among T2DM (57.80% (95% CI: 50.50\u201065.10), <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 92.5<jats:italic>%<\/jats:italic>), studies that used probability sampling technique (59.09% (95% CI: 43.58\u201074.59), <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 98.6<jats:italic>%<\/jats:italic>, <jats:italic>p<\/jats:italic> &lt; 0.001), and studies from primary data sources (51.43% (95% CI: 40.72\u201062.13), <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 98.0<jats:italic>%<\/jats:italic>, <jats:italic>p<\/jats:italic> &lt; 0.001). Moreover, the estimated pooled prevalence of the total plasma cholesterol (TC \u2265 200\u2009mg\/dl) was 34.08% (95% CI: 28.41\u201039.75, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 92.4<jats:italic>%<\/jats:italic>), LDL \u2212 C \u2265 100\u2009mg\/dl was 41.13% (95% CI: 27.15\u201055.11, I<jats:sup>2<\/jats:sup> =\u200998.8%), and HDL \u2264 40\u2009mg\/dl\u2009for\u2009men\u2009and \u2264 50\u2009mg\/dl\u2009for\u2009women was 44.36% (95% CI: 31.82\u201056.90, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 98.8<jats:italic>%<\/jats:italic>). <jats:italic>Conclusions<\/jats:italic>. The pooled prevalence of hypertriglyceridemia and other lipid abnormalities among DM patients was relatively high in Ethiopia. It strongly suggests the need to give maximal attention to the adherence of DM management to reduce the circulatory lipid profile abnormalities and subsequent complications. <jats:italic>Prospero Registration<\/jats:italic>. <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42020182291\">CRD42020182291<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2021\/7389076","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T18:50:15Z","timestamp":1620759015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hypertriglyceridemia and Other Plasma Lipid Profile Abnormalities among People Living with Diabetes Mellitus in Ethiopia: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2397-5930","authenticated-orcid":false,"given":"Baye","family":"Dagnew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-7925","authenticated-orcid":false,"given":"Yigizie","family":"Yeshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8493-1512","authenticated-orcid":false,"given":"Demeke","family":"Geremew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-2255","authenticated-orcid":false,"given":"Dessie Abebaw","family":"Angaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7161-0904","authenticated-orcid":false,"given":"Henok","family":"Dagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2835-0964","authenticated-orcid":false,"given":"Mekuriaw","family":"Alemayehu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2622-522X","authenticated-orcid":false,"given":"Meseret Derbew","family":"Molla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0914-7768","authenticated-orcid":false,"given":"Yonas","family":"Akalu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet1066"},{"key":"e_1_2_11_2_2","doi-asserted-by":"crossref","unstructured":"HoustonM. The role of noninvasive cardiovascular testing applied clinical nutrition and nutritional supplements in the prevention and treatment of coronary heart disease Therapeutic Advances in Cardiovascular Disease 2018 12 no. 3 85\u2013108.","DOI":"10.1177\/1753944717743920"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3525-8"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.04.062"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.18926\/AMO\/61441"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.600323"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-037340"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1496"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi200711v"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2021.2147"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-016-0167-x"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2008.05.014"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.3.7304"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9419413"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-019-4550-3"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.08.009"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000219611.50066.bd"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw272"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0023-5"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2019.07.004"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.2147\/dmso.s283171"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.2147\/dmso.s135064"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2013.02.011"},{"key":"e_1_2_11_24_2","unstructured":"WHO Global Health Observatory (GHO) data Mean cholesterol Situation and trends 2020 https:\/\/www.who.int\/gho\/ncd\/risk_factors\/cholesterol_mean_text\/en\/."},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31012-1"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2015.10.009"},{"key":"e_1_2_11_27_2","first-page":"21","article-title":"Prevalence and pattern of dyslipidemia in diabetes mellitus patients admitted in the Department of Cardiology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh","volume":"30","author":"Bhuiyan A. S.","year":"2021","journal-title":"Mymensingh medical journal : MMJ"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1034-3"},{"key":"e_1_2_11_29_2","first-page":"24","article-title":"Prevalence and pattern of dyslipidemia in type 2 diabetes mellitus patients in a rural tertiary care centre, southern India","volume":"1","author":"Jayarama N.","year":"2012","journal-title":"Global Journal of Medicine & Public Health"},{"key":"e_1_2_11_30_2","first-page":"1","article-title":"Analysis of serum lipids and lipoproteins in Ethiopian diabetic patients","volume":"41","author":"Seyoum B.","year":"2003","journal-title":"Ethiopian medical journal"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.2147\/dmso.s185614"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8896896"},{"key":"e_1_2_11_33_2","volume-title":"CRD\u2019s Guidance for Undertaking Reviews in Health Care","author":"Dissemination C.","year":"2009"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2010.11.001"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.11.014"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/0470870168.ch1"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"e_1_2_11_41_2","first-page":"3","article-title":"Factors associated with the occurrence of hypertension and dyslipidemia among diabetic patients attending the diabetes clinic of Ayder Comprehensive Specialized Hospital, Mekelle, Ethiopia","volume":"1","author":"Abera M. A.","year":"2019","journal-title":"East African Journal of Health Sciences"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.5897\/jde2015.0086"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6156.1000454"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.4314\/ejhs.v28i5.16"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-018-0880-7"},{"key":"e_1_2_11_46_2","volume-title":"Assessment of metabolic syndrome in relation to sex among type \u0399\u0399 diabetes mellitus patients in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia","author":"Birlie M.","year":"2019"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-019-0421-0"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.4314\/epj.v31i2.5"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1080\/21623945.2018.1467716"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2005.08.002"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.21767\/1791-809x.1000509"},{"key":"e_1_2_11_52_2","unstructured":"TeferaB. Insulin Resistance and Dyslipidemia in Type 2 Diabetic Patients: a Cross-Sectional Study at the Diabetic Clinic of Tikur Anbessa Specialized Teaching Hospital [Ph.D thesis] 2015 Addis Ababa University."},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-018-0280-0"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-017-0226-y"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.5897\/jde2019.0132"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.15226\/2374-6890\/4\/1\/00170"},{"key":"e_1_2_11_58_2","unstructured":"PandyaH. LakhaniJ. DadhaniaJ. andTrivediA. The Prevalence and Pattern of Dyslipidemia among Type 2 Diabetic Patients at Rural Based Hospital in Gujarat India Indian Journal of Clinical Practice 2012 22 no. 12 640\u2013648."},{"key":"e_1_2_11_59_2","first-page":"1423","article-title":"Prevalence of dyslipidemia in patients with type 2 diabetes in Jordan","volume":"29","author":"Abdel-Aal N. M.","year":"2008","journal-title":"Saudi Medical Journal"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9020226"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.3.7304"},{"key":"e_1_2_11_62_2","first-page":"180","article-title":"Lipid metabolism. I. Role of insulin in lipid metabolism","volume":"10","author":"Otto-Buczkowska E.","year":"2001","journal-title":"Polski Merkuriusz Lekarski"},{"key":"e_1_2_11_63_2","first-page":"147","article-title":"Lipid profile among diabetes patients in Gaborone, Botswana","volume":"96","author":"Mengesha A. Y.","year":"2006","journal-title":"Suid-Afrikaanse tydskrif vir geneeskunde"},{"key":"e_1_2_11_64_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S215548"},{"key":"e_1_2_11_65_2","doi-asserted-by":"publisher","DOI":"10.24966\/cmph-1978\/100048"},{"key":"e_1_2_11_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2012.05.002"},{"key":"e_1_2_11_67_2","article-title":"Prevalence and determinants of dyslipidemia: data from a Saudi University Clinic","volume":"11","author":"Yasser Taher Al-Hassan E. L. F.","year":"2018","journal-title":"The Open Public Health Journal"},{"key":"e_1_2_11_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205709"},{"key":"e_1_2_11_69_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2013.37.6.433"},{"key":"e_1_2_11_70_2","unstructured":"FeingoldK. R.andGrunfeldC. Diabetes and dyslipidemia Endotext 2019 MDText.com Inc."},{"key":"e_1_2_11_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.12.069"},{"key":"e_1_2_11_72_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017326"},{"key":"e_1_2_11_73_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-013-0418-7"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/7389076.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/7389076.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/7389076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T14:11:51Z","timestamp":1735654311000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/7389076"}},"subtitle":[],"editor":[{"given":"Carlos R.","family":"Bueno Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/7389076"],"URL":"https:\/\/doi.org\/10.1155\/2021\/7389076","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7389076"}}