{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:47:58Z","timestamp":1784738878829,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HB16C0043"],"award-info":[{"award-number":["HB16C0043"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HB16C0043"],"award-info":[{"award-number":["HB16C0043"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,3,24]]},"abstract":"<jats:p>Background. Migraine is a common reason for primary headache disorders. Cupping is a frequently used traditional intervention for controlling pain including migraine. There have been no systematic reviews on the clinical effects of cupping on migraine. Objective. This systematic review and meta-analysis aimed to evaluate the effectiveness of cupping therapy for migraine. The search strategy was built for the presence of related keywords, such as \u201cmigraine\u201d and \u201ccupping therapy\u201d, in the title and abstract of research articles indexed in the MEDLINE, EMBASE, CENTRAL, and other databases. The randomized controlled trials (RCTs) of cupping therapy for migraine were searched and selected from inception to May 2019. We searched eight databases including PubMed, EMBASE, Cochrane Central Register of Controlled Trials. The selection process and the quality assessment were performed by 2 authors independently. The meta-analysis was conducted and qualitative analysis was also performed. Results. 218 studies were identified, and 6 RCTs were enrolled in this review. In comparison to drugs, wet cupping showed a higher total effective rate (TER). In the dry cupping plus acupuncture, the result of TER showed more effectiveness (RR 1.05, 95% CI 0.99 to 1.12, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.13<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) compared with acupuncture alone, but there was no statistically significant difference. In qualitative analysis, the results showed wet cupping plus drugs treatment could quickly relieve pain and significantly improve patients\u2019 quality of life and wet cupping could reduce headache pain. Conclusion. Cupping therapy could be effective for the treatment of migraine. However, the qualities of the evidence were low, so well-designed RCTs are needed to confirm the effectiveness of cupping. Systematic review registration: PROSPERO registration number is CRD42017054979.<\/jats:p>","DOI":"10.1155\/2021\/7582581","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T15:56:06Z","timestamp":1616687766000},"page":"1-9","source":"Crossref","is-referenced-by-count":14,"title":["Cupping Therapy for Migraine: A PRISMA-Compliant Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9865-1543","authenticated-orcid":true,"given":"Jihye","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Oriental Gynecology, Se-Myung University Korean Medicine Hospital, Republic of Korea"},{"name":"Department of Internal Medicine and Neuroscience, College of Korean Medicine, Wonkwang University, Iksan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0171-0234","authenticated-orcid":true,"given":"Hongmin","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Neuroscience, College of Korean Medicine, Wonkwang University, Iksan, Republic of Korea"},{"name":"Department of Internal Medicine, Wonkwang University Gwangju Korean Medicine Hospital, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-1117","authenticated-orcid":true,"given":"Cheol-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Neuroscience, College of Korean Medicine, Wonkwang University, Iksan, Republic of Korea"},{"name":"Department of Internal Medicine, Wonkwang University Gwangju Korean Medicine Hospital, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4050-0977","authenticated-orcid":true,"given":"Kang-Keyng","family":"Sung","sequence":"additional","affiliation":[{"name":"Internal Medicine and Neuroscience, Jangheung Integrative Medical Hospital, Wonkwang University, Iksan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8674-1712","authenticated-orcid":true,"given":"Sangkwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Neuroscience, College of Korean Medicine, Wonkwang University, Iksan, Republic of Korea"},{"name":"Department of Internal Medicine, Wonkwang University Gwangju Korean Medicine Hospital, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"1","article-title":"The international classification of headache disorders","volume":"38","author":"Headache Classification Committee of the International Headache Society (IHS)","year":"2018","journal-title":"Cephalalgia: An International Journal of Headache"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1474-4422(18)30499-X","article-title":"Global, regional, and national burden of neurological disorders, 1990\u20132016: a systematic analysis for the global burden of disease study 2016","volume":"18","author":"V. L. Feigin","year":"2019","journal-title":"The Lancet Neurology"},{"issue":"2","key":"3","first-page":"S23","article-title":"Migraine overview and summary of current and emerging treatment options","volume":"25","author":"G. L. Peters","year":"2019","journal-title":"The American Journal of Managed Care"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0b013e3182535d20"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318580"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2015.1043265"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j1805"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-019-0750-8"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031793"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s2095-4964(17)60339-x"},{"issue":"6","key":"11","first-page":"48","article-title":"Wet cupping therapy for treatment of herpes zoster: a systematic review of randomized controlled trials","volume":"16","author":"H. 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Li","year":"2012","journal-title":"Clinical Journal of Chinese Medicine"},{"issue":"1","key":"25","first-page":"17","article-title":"Observations on the efficacy of acupuncture at point shanzhong(CV17) plus cupping on back-shu points in treating migraine","volume":"34","author":"S. S. Jin","year":"2015","journal-title":"Shanghai Journal of Acupuncture and Moxibustion"},{"issue":"1","key":"26","first-page":"46","article-title":"Clinical efficacy of collateral pricking and cupping combined with rizatriptan benzoate in treatment of 65 patients with acute episode migraine","volume":"44","author":"Y. Zhang","year":"2020","journal-title":"Journal of Shandong University of Traditional Chinese Medicine"},{"issue":"27","key":"27","first-page":"26","article-title":"The difference between acupuncture and collaterals bloodletting and western medicine in treating migraine","volume":"11","author":"L. Chen","year":"2019","journal-title":"Clinical Journal of Chinese Medicine"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/7582581.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/7582581.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/7582581.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T15:56:17Z","timestamp":1616687777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/7582581\/"}},"subtitle":[],"editor":[{"given":"Arthur","family":"De S\u00e1 Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,24]]},"references-count":27,"alternative-id":["7582581","7582581"],"URL":"https:\/\/doi.org\/10.1155\/2021\/7582581","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,24]]}}}