{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:00:51Z","timestamp":1761897651823,"version":"3.41.2"},"reference-count":124,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":361,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004710","name":"Fondazione Umberto Veronesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","award":["2105-50-11-2018"],"award-info":[{"award-number":["2105-50-11-2018"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Pterostilbene (Pt) is a potentially beneficial plant phenol. In contrast to many other natural compounds (including the more celebrated resveratrol), Pt concentrations producing significant effects <jats:italic>in vitro<\/jats:italic> can also be reached with relative ease <jats:italic>in vivo<\/jats:italic>. Here we focus on some of the mechanisms underlying its activity, those involved in the activation of transcription factor EB (TFEB). A set of processes leading to this outcome starts with the generation of ROS, attributed to the interaction of Pt with complex I of the mitochondrial respiratory chain, and spreads to involve Ca<jats:sup>2+<\/jats:sup> mobilization from the ER\/mitochondria pool, activation of CREB and AMPK, and inhibition of mTORC1. TFEB migration to the nucleus results in the upregulation of autophagy and lysosomal and mitochondrial biogenesis. Cells exposed to several <jats:italic>\u03bc<\/jats:italic>M levels of Pt experience a mitochondrial crisis, an indication for using low doses in therapeutic or nutraceutical applications. Pt afforded significant functional improvements in a zebrafish embryo model of ColVI\u2010related myopathy, a pathology which also involves defective autophagy. Furthermore, long\u2010term supplementation with Pt reduced body weight gain and increased transcription levels of <jats:italic>Ppargc1a<\/jats:italic> and <jats:italic>Tfeb<\/jats:italic> in a mouse model of diet\u2010induced obesity. These <jats:italic>in vivo<\/jats:italic> findings strengthen the <jats:italic>in vitro<\/jats:italic> observations and highlight the therapeutic potential of this natural compound.<\/jats:p>","DOI":"10.1155\/2021\/7658501","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T22:20:18Z","timestamp":1640730018000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multiple Mechanisms Converging on Transcription Factor EB Activation by the Natural Phenol Pterostilbene"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-2599","authenticated-orcid":false,"given":"Martina","family":"La Spina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0619-3523","authenticated-orcid":false,"given":"Michele","family":"Azzolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Salmaso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7106-6451","authenticated-orcid":false,"given":"Sofia","family":"Parrasia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9060-5027","authenticated-orcid":false,"given":"Eva","family":"Galletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8566-5559","authenticated-orcid":false,"given":"Marco","family":"Schiavone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5328-1737","authenticated-orcid":false,"given":"Martina","family":"Chrisam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2023-0749","authenticated-orcid":false,"given":"Andrea","family":"Mattarei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1489-3896","authenticated-orcid":false,"given":"Giulietta","family":"Di Benedetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1381-4604","authenticated-orcid":false,"given":"Andrea","family":"Ballabio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5444-9853","authenticated-orcid":false,"given":"Natascia","family":"Tiso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-2524","authenticated-orcid":false,"given":"Mario","family":"Zoratti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7638-6865","authenticated-orcid":false,"given":"Lucia","family":"Biasutto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2016.10.005"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3735"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.08.018"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R117.810739"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070674"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.007"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108863"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00551-9"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166262"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.111061"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2018.2213"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01129"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2020.12.004"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2021.06.002"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2021.04.001"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.128547"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.113812"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.240465"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6617256"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3259963"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2021.119041"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5583215"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174447"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204592"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.146365"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00114"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201798804"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.609683"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004754"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040901"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109442"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101465"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.01.028"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.10.005"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01071"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.53"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010159"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.26336"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep21772"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.748149"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.105188"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmab042"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030813"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.111501"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2017.02.013"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.1.230S"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200500010"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05842.x"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2013.805182"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.09.054"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/575482"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b07860"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1254"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-010-1525-4"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200651"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400244"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf202846b"},{"key":"e_1_2_11_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf2000103"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.08.015"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.01.009"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044524"},{"key":"e_1_2_11_62_2","first-page":"545","article-title":"Pterostilbene induces accumulation of autophagic vacuoles followed by cell death in HL60 human leukemia cells","volume":"64","author":"Siedlecka-Kroplewska K.","year":"2013","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_11_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.03.007"},{"key":"e_1_2_11_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215377"},{"key":"e_1_2_11_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2247"},{"key":"e_1_2_11_66_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573399812666160217122530"},{"key":"e_1_2_11_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.32"},{"key":"e_1_2_11_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(90)90059-4"},{"key":"e_1_2_11_69_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_11_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2014.06.010"},{"key":"e_1_2_11_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq126"},{"key":"e_1_2_11_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.06.040"},{"key":"e_1_2_11_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr306"},{"key":"e_1_2_11_74_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5432"},{"key":"e_1_2_11_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.08.030"},{"key":"e_1_2_11_76_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1704104"},{"key":"e_1_2_11_77_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3809308"},{"key":"e_1_2_11_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.05.032"},{"key":"e_1_2_11_79_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706536200"},{"key":"e_1_2_11_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.017"},{"key":"e_1_2_11_81_2","doi-asserted-by":"publisher","DOI":"10.33594\/000000017"},{"key":"e_1_2_11_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-12457-1_29"},{"key":"e_1_2_11_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.10.016"},{"key":"e_1_2_11_84_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14212"},{"key":"e_1_2_11_85_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan5835"},{"key":"e_1_2_11_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3114"},{"key":"e_1_2_11_87_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13412"},{"key":"e_1_2_11_88_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0109-15.2015"},{"key":"e_1_2_11_89_2","first-page":"71","article-title":"Compared flow cytometric analysis of mitochondria using 10-n-nonyl Acridine Orange and rhodamine 123","volume":"33","author":"Benel L.","year":"1989","journal-title":"Basic and Applied Histochemistry"},{"key":"e_1_2_11_90_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx005"},{"key":"e_1_2_11_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2017.03.005"},{"key":"e_1_2_11_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2016.10.028"},{"key":"e_1_2_11_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.125336"},{"key":"e_1_2_11_94_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1580511"},{"key":"e_1_2_11_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.12.008"},{"key":"e_1_2_11_96_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1108508"},{"key":"e_1_2_11_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2718"},{"key":"e_1_2_11_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2017.02.017"},{"key":"e_1_2_11_99_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003471"},{"key":"e_1_2_11_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.04.050"},{"key":"e_1_2_11_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05862-6"},{"key":"e_1_2_11_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.06.005"},{"key":"e_1_2_11_103_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162784"},{"key":"e_1_2_11_104_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1596489"},{"key":"e_1_2_11_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12109"},{"key":"e_1_2_11_106_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006886215193"},{"key":"e_1_2_11_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.01.012"},{"key":"e_1_2_11_108_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201501002"},{"key":"e_1_2_11_109_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13820"},{"key":"e_1_2_11_110_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1061172"},{"key":"e_1_2_11_111_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612820666140305224906"},{"key":"e_1_2_11_112_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf7478"},{"key":"e_1_2_11_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.11.003"},{"key":"e_1_2_11_114_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aau2281"},{"key":"e_1_2_11_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/35093131"},{"key":"e_1_2_11_116_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160009"},{"key":"e_1_2_11_117_2","doi-asserted-by":"publisher","DOI":"10.1042\/bse0470069"},{"key":"e_1_2_11_118_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.580933"},{"key":"e_1_2_11_119_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-0602-4_17"},{"key":"e_1_2_11_120_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01193"},{"key":"e_1_2_11_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.06.014"},{"key":"e_1_2_11_122_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114041"},{"key":"e_1_2_11_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2015.07.017"},{"key":"e_1_2_11_124_2","unstructured":"La SpinaM. Pharmacology biochemistry and biomedical applications of plant stilbenes [Ph.D. thesis] 2017 University of Padova http:\/\/paduaresearch.cab.unipd.it\/10120\/1\/laspina_martina_tesi.pdf."}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/7658501.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/7658501.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/7658501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:54:17Z","timestamp":1723056857000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/7658501"}},"subtitle":[],"editor":[{"given":"FRANCO","family":"J. L","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":124,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/7658501"],"URL":"https:\/\/doi.org\/10.1155\/2021\/7658501","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"type":"print","value":"1942-0900"},{"type":"electronic","value":"1942-0994"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7658501"}}