{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:13:32Z","timestamp":1773288812303,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["20-04-60251\\20"],"award-info":[{"award-number":["20-04-60251\\20"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2021,12,16]]},"abstract":"<jats:p>\n                    Objective. S-Adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are indicators of global transmethylation and may play an important role as markers of severity of COVID-19. Methods. The levels of plasma SAM and SAH were determined in patients admitted with COVID-19 (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>n<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>56<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ,\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>mean<\/c:mtext>\n                        <c:mtext>\u2009<\/c:mtext>\n                        <c:mtext>age<\/c:mtext>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>61<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). Lung injury was identified by computed tomography (CT) in accordance with the CT0-4 classification. Results. SAM was found to be a potential marker of lung damage risk in COVID-19 patients (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>SAM<\/e:mtext>\n                        <e:mo>&gt;<\/e:mo>\n                        <e:mn>80<\/e:mn>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>nM<\/e:mtext>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ; CT3,4 vs. CT 0-2: relative ratio (RR) was 3.0;\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.0029<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ).\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mtext>SAM<\/i:mtext>\n                        <i:mo>\/<\/i:mo>\n                        <i:mtext>SAH<\/i:mtext>\n                        <i:mo>&gt;<\/i:mo>\n                        <i:mn>6.0<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    was also found to be a marker of lung injury (CT2-4 vs. CT0,1:\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mtext>RR<\/k:mtext>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>3.47<\/k:mn>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    ,\n                    <jats:inline-formula>\n                      <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.0004<\/m:mn>\n                      <\/m:math>\n                    <\/jats:inline-formula>\n                    ). There was a negative association between SAM and glutathione level (\n                    <jats:inline-formula>\n                      <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>\u03c1<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mo>\u2212<\/o:mo>\n                        <o:mn>0.343<\/o:mn>\n                      <\/o:math>\n                    <\/jats:inline-formula>\n                    ,\n                    <jats:inline-formula>\n                      <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>p<\/q:mi>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>0.011<\/q:mn>\n                      <\/q:math>\n                    <\/jats:inline-formula>\n                    ). Interleukin-6 (IL-6) levels were associated with SAM (\n                    <jats:inline-formula>\n                      <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>\u03c1<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.44<\/s:mn>\n                      <\/s:math>\n                    <\/jats:inline-formula>\n                    ,\n                    <jats:inline-formula>\n                      <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>p<\/u:mi>\n                        <u:mo>=<\/u:mo>\n                        <u:mn>0.01<\/u:mn>\n                      <\/u:math>\n                    <\/jats:inline-formula>\n                    ) and SAH (\n                    <jats:inline-formula>\n                      <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:mi>\u03c1<\/w:mi>\n                        <w:mo>=<\/w:mo>\n                        <w:mn>0.534<\/w:mn>\n                      <\/w:math>\n                    <\/jats:inline-formula>\n                    ,\n                    <jats:inline-formula>\n                      <y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\">\n                        <y:mi>p<\/y:mi>\n                        <y:mo>=<\/y:mo>\n                        <y:mn>0.001<\/y:mn>\n                      <\/y:math>\n                    <\/jats:inline-formula>\n                    ) levels. Conclusions. A high SAM level and high methylation index are associated with the risk of lung injury in patients with COVID-19. The association of SAM with IL-6 and glutathione indicates an important role of transmethylation in the development of cytokine imbalance and oxidative stress in patients with COVID-19.\n                  <\/jats:p>","DOI":"10.1155\/2021\/7686374","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T16:35:11Z","timestamp":1639672511000},"page":"1-10","source":"Crossref","is-referenced-by-count":19,"title":["Plasma S-Adenosylmethionine Is Associated with Lung Injury in COVID-19"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8396-1936","authenticated-orcid":true,"given":"Evgeny Vladimirovich","family":"Kryukov","sequence":"first","affiliation":[{"name":"Burdenko Main Military Clinical Hospital, Ministry of Defense, Gospitalnaya Sq., 3, Moscow, 105229, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2424-6115","authenticated-orcid":true,"given":"Alexander 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Moscow, 125315, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-160X","authenticated-orcid":true,"given":"Maria Petrovna","family":"Kruglova","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Trubetskaya St., 8-2, Moscow, 119991, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennady Ivanovich","family":"Kostiuchenko","sequence":"additional","affiliation":[{"name":"Regional Clinical Hospital, Lyapidevsky St., 1, Barnaul, 656024, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergei Petrovich","family":"Kazakov","sequence":"additional","affiliation":[{"name":"Burdenko Main Military Clinical Hospital, Ministry of Defense, Gospitalnaya Sq., 3, Moscow, 105229, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8077-2905","authenticated-orcid":true,"given":"Aslan 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