{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:18:51Z","timestamp":1768468731935,"version":"3.49.0"},"reference-count":100,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Natural Fund","award":["19ZR1456500"],"award-info":[{"award-number":["19ZR1456500"]}]},{"name":"Shanghai Natural Fund","award":["20WQ011"],"award-info":[{"award-number":["20WQ011"]}]},{"name":"Innovation and Generation of Military Medical Support Capability","award":["19ZR1456500"],"award-info":[{"award-number":["19ZR1456500"]}]},{"name":"Innovation and Generation of Military Medical Support Capability","award":["20WQ011"],"award-info":[{"award-number":["20WQ011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:p>Background. Osteoarthritis (OA) is a clinical joint degenerative disease, the pathogenic factors of which include age, obesity, and mechanical injury. Its main pathological features include cartilage loss, narrowing of joint space, and osteophyte formation. At present, there are a variety of treatment methods for OA. Natural products, which are gradually being applied in the treatment of OA, are advantageous as they present with low toxicity and low costs and act on multiple targets. Methods. The terms \u201cnatural products,\u201d \u201costeoarthritis,\u201d and \u201cchondrocytes\u201d were searched in PubMed to screen the related literature in the recent 10 years. Results. We comprehensively introduced 62 published papers on 48 natural products involving 6, 3, 5, 12, 4, and 5 kinds of terpenoids, polysaccharides, polyphenols, flavonoids, alkaloids, and saponins, respectively (and others). Conclusion. The mechanisms of their anti-OA action mainly involve reducing the production of inflammatory factors, reducing oxidative stress, regulating the metabolism of chondrocytes, promoting the proliferation of chondrocytes, or inhibiting chondrocyte apoptosis. This article summarizes the anti-OA activity of natural products in the last 10 years and provides candidate monomers for further study for use in OA treatment.<\/jats:p>","DOI":"10.1155\/2021\/7714533","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T21:27:57Z","timestamp":1633037277000},"page":"1-17","source":"Crossref","is-referenced-by-count":9,"title":["Research Progress on the Antiosteoarthritic Mechanism of Action of Natural Products"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9002-3390","authenticated-orcid":true,"given":"Mingzhu","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China"},{"name":"Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, China"},{"name":"College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China"},{"name":"Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, China"},{"name":"College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Bian","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-6497","authenticated-orcid":true,"given":"Luping","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-4598","authenticated-orcid":true,"given":"Leilei","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China"},{"name":"Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, China"},{"name":"Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"6","key":"1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.4085\/1062-6050-51.5.08","article-title":"Epidemiology of posttraumatic osteoarthritis","volume":"52","author":"A. C. Thomas","year":"2017","journal-title":"Journal of Athletic Training"},{"issue":"1","key":"2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/03008207.2016.1208655","article-title":"Inflammation and epigenetic regulation in osteoarthritis","volume":"58","author":"J. Shen","year":"2017","journal-title":"Connective Tissue Research"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5190986"},{"issue":"11","key":"4","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11926-018-0782-9","article-title":"Natural products for promoting joint health and managing osteoarthritis","volume":"20","author":"Y. Henrotin","year":"2018","journal-title":"Current Rheumatology Reports"},{"key":"5","first-page":"63","article-title":"Biosynthesis and biological functions of terpenoids in plants","volume":"148","author":"D. Tholl","year":"2015","journal-title":"Advances in Biochemical Engineering"},{"key":"6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113739","article-title":"Current status of terpenoids as inflammasome inhibitors","volume":"172","author":"S. Hortelano","year":"2020","journal-title":"Biochemical Pharmacology"},{"issue":"12","key":"7","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1517\/13543784.2012.727395","article-title":"Terpenoids: natural products for cancer therapy","volume":"21","author":"M. Huang","year":"2012","journal-title":"Expert Opinion on Investigational Drugs"},{"key":"8","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21121705","article-title":"Polysaccharides from traditional Chinese medicines: extraction, purification, modification, and biological activity","volume":"21","author":"Y. Chen","year":"2016","journal-title":"Molecules"},{"key":"9","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.ejmech.2017.08.048","article-title":"Recent advances in polysaccharides for osteoarthritis therapy","volume":"139","author":"Q. Chen","year":"2017","journal-title":"European Journal of Medicinal Chemistry"},{"issue":"2","key":"10","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1080\/10408398.2012.752342","article-title":"Polyphenol conjugates and human health: a perspective review","volume":"56","author":"G. Cirillo","year":"2016","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jep.2017.08.035","article-title":"Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases","volume":"210","author":"Q. Y. Eng","year":"2018","journal-title":"Journal of Ethnopharmacology"},{"issue":"5","key":"12","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/med.21565","article-title":"Health benefits of resveratrol: evidence from clinical studies","volume":"39","author":"A. P. Singh","year":"2019","journal-title":"Medicinal Research Reviews"},{"key":"13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.intimp.2018.08.037","article-title":"Piceatannol attenuates D-GalN\/LPS-induced hepatoxicity in mice: involvement of ER stress, inflammation and oxidative stress","volume":"64","author":"J. Wen","year":"2016","journal-title":"International Immunopharmacology"},{"key":"14","article-title":"Pterostilbene: mechanisms of its action as oncostatic agent in cell models and in vivo studies","volume":"145","author":"Z. Ma","year":"2019","journal-title":"Pharmacological Research"},{"issue":"2","key":"15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41419-017-0166-5","article-title":"Honokiol induces apoptosis and autophagy via the ROS\/ERK1\/2 signaling pathway in human osteosarcoma cells in vitro and in vivo","volume":"9","author":"K. Huang","year":"2018","journal-title":"Cell Death and Disease"},{"issue":"13","key":"16","article-title":"Regulatory roles of flavonoids on inflammasome activation during inflammatory responses","volume":"62","author":"Y. S. Yi","year":"2018","journal-title":"Molecular Nutrition and Food Research"},{"issue":"19","key":"17","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1021\/acs.jafc.8b05348","article-title":"Flavonoids alleviating insulin resistance through inhibition of inflammatory signaling","volume":"67","author":"N. Ren","year":"2019","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"18","article-title":"Alkaloids from traditional Chinese medicine against hepatocellular carcinoma","volume":"120","author":"C. Liu","year":"2019","journal-title":"Biomedicine and Pharmacotherapy"},{"issue":"4","key":"19","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.bbrc.2018.02.018","article-title":"Functional and structural characterization of a beta-glucosidase involved in saponin metabolism from intestinal bacteria","volume":"496","author":"S. Yan","year":"2018","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-1-4939-6445-1_4","article-title":"Semisynthesis of analogues of the saponin immunoadjuvant QS-21","volume":"1494","author":"A. Fernandez-Tejada","year":"2017","journal-title":"Methods in Molecular Biology"},{"issue":"1","key":"21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5582\/ddt.2015.01004","article-title":"Chemical constituents and bioactivities of Panax ginseng (C. A. Mey.)","volume":"9","author":"W. Ru","year":"2015","journal-title":"Drug Discoveries and Therapeutics"},{"issue":"3","key":"22","article-title":"Metabolomic mechanisms of gypenoside against liver fibrosis in rats: an integrative analysis of proteomics and metabolomics data","volume":"12","author":"Y. N. Song","year":"2017","journal-title":"PLoS One"},{"issue":"1-3","key":"23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2010.06.034","article-title":"Tenuigenin protects cultured hippocampal neurons against methylglyoxal-induced neurotoxicity","volume":"645","author":"Y. J. Chen","year":"2010","journal-title":"European Journal of Pharmacology"},{"key":"24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jpba.2019.03.041","article-title":"Chemical and metabolic analysis of Achyranthes bidentate saponins with intestinal microflora-mediated biotransformation by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry coupled with metabolism platform","volume":"170","author":"J. Fu","year":"2019","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"25","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.chroma.2019.02.055","article-title":"Revelation of the metabolic pathway of hederacoside C using an innovative data analysis strategy for dynamic multiclass biotransformation experiments","volume":"1595","author":"L. Peeters","year":"2019","journal-title":"Journal of Chromatography A"},{"issue":"3","key":"26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1875-5364(15)30002-9","article-title":"Salvia miltiorrhiza: traditional medicinal uses, chemistry, and pharmacology","volume":"13","author":"C. Y. Su","year":"2015","journal-title":"Chinese Journal of Natural Medicines"},{"issue":"7","key":"27","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1248\/cpb.c18-00968","article-title":"Determination of schisandrin A and schisandrin B in traditional Chinese medicine preparation huganpian tablet by RP-HPLC","volume":"67","author":"B. Yu","year":"2019","journal-title":"Chemical and Pharmaceutical Bulletin"},{"issue":"1","key":"28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40659-019-0241-8","article-title":"Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells","volume":"52","author":"X. Wang","year":"2019","journal-title":"Biological Research"},{"key":"29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.biopha.2018.08.145","article-title":"Bergapten inhibits liver carcinogenesis by modulating LXR\/PI3K\/Akt and IDOL\/LDLR pathways","volume":"108","author":"S. P. Pattanayak","year":"2018","journal-title":"Biomedicine and Pharmacotherapy"},{"issue":"3","key":"30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ygeno.2014.07.013","article-title":"Analysis of the transcriptome of Marsdenia tenacissima discovers putative polyoxypregnane glycoside biosynthetic genes and genetic markers","volume":"104","author":"K. Zheng","year":"2014","journal-title":"Genomics"},{"issue":"4","key":"31","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4196\/kjpp.2018.22.4.391","article-title":"Anti-inflammatory and utero-relaxant effect of alpha-bisabolol on the pregnant human uterus","volume":"22","author":"V. M. Munoz-Perez","year":"2018","journal-title":"Korean Journal of Physiology and Pharmacology"},{"issue":"1","key":"32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12906-017-1581-y","article-title":"Protective effects of aucubin on osteoarthritic chondrocyte model induced by hydrogen peroxide and mechanical stimulus","volume":"17","author":"I. C. Young","year":"2017","journal-title":"BMC Complementary and Alternative Medicine"},{"key":"33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.intimp.2018.07.014","article-title":"Abietic acid attenuates IL-1beta-induced inflammation in human osteoarthritis chondrocytes","volume":"64","author":"S. Kang","year":"2018","journal-title":"International Immunopharmacology"},{"key":"34","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ijbiomac.2016.02.031","article-title":"Polysaccharide from Angelica sinensis protects chondrocytes from H2O2-induced apoptosis through its antioxidant effects in vitro","volume":"87","author":"C. Zhuang","year":"2016","journal-title":"International Journal of Biological Macromolecules"},{"issue":"2","key":"35","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.joca.2009.08.015","article-title":"Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate","volume":"18","author":"L. F. Heinecke","year":"2010","journal-title":"Osteoarthritis and Cartilage"},{"issue":"4","key":"36","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/jor.22577","article-title":"Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes","volume":"32","author":"Y. J. Chen","year":"2014","journal-title":"Journal of Orthopaedic Research"},{"issue":"4","key":"37","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.bbrc.2016.06.126","article-title":"Biochanin-A antagonizes the interleukin-1beta-induced catabolic inflammation through the modulation of NFkappaB cellular signaling in primary rat chondrocytes","volume":"477","author":"J. S. Oh","year":"2016","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"38","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.biopha.2018.01.041","article-title":"Baicalin alleviates IL-1beta-induced inflammatory injury via down-regulating miR-126 in chondrocytes","volume":"99","author":"X. Yang","year":"2018","journal-title":"Biomedicine and Pharmacotherapy"},{"key":"39","article-title":"Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2\/HO-1 and NF-kappaB signaling pathways","volume":"75","author":"Y. Wu","year":"2019","journal-title":"International Immunopharmacology"},{"issue":"1","key":"40","first-page":"1493","article-title":"Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis","volume":"17","author":"Y. Wei","year":"2018","journal-title":"Molecular Medicine Reports"},{"issue":"12","key":"41","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1002\/art.41429","article-title":"The role of the non-neuronal cholinergic system in inflammation and degradation processes in osteoarthritis","volume":"72","author":"A Courties","year":"2020","journal-title":"Arthritis and Rheumatism"},{"issue":"4","key":"42","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/08923973.2019.1637890","article-title":"Astragaloside inhibits IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice","volume":"41","author":"H. Li","year":"2019","journal-title":"Immunopharmacology and Immunotoxicology"},{"issue":"5","key":"43","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.3892\/mmr.2017.7340","article-title":"Articular cartilage degradation is prevented by tanshinone IIA through inhibiting apoptosis and the expression of inflammatory cytokines","volume":"16","author":"P. T. Jia","year":"2017","journal-title":"Molecular Medicine Reports"},{"key":"44","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.intimp.2017.02.021","article-title":"Salvianolic acid B inhibits IL-1beta-induced inflammatory cytokine production in human osteoarthritis chondrocytes and has a protective effect in a mouse osteoarthritis model","volume":"46","author":"Y. Lou","year":"2017","journal-title":"International Immunopharmacology"},{"key":"45","article-title":"FlexPro MD(R), a combination of krill oil, astaxanthin and hyaluronic acid, reduces pain behavior and inhibits inflammatory response in monosodium iodoacetate-induced osteoarthritis in rats","volume":"12","author":"M. H. Park","year":"2020","journal-title":"Nutrients"},{"issue":"6","key":"46","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/rheumatology\/kes363","article-title":"Delphinidin inhibits IL-1beta-induced activation of NF-kappaB by modulating the phosphorylation of IRAK-1(Ser376) in human articular chondrocytes","volume":"52","author":"A. Haseeb","year":"2013","journal-title":"Rheumatology"},{"issue":"6","key":"47","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/2211-5463.12648","article-title":"Bergapten alleviates osteoarthritis by regulating the ANP32A\/ATM signaling pathway","volume":"9","author":"Y. He","year":"2019","journal-title":"FEBS Open Bio"},{"key":"48","article-title":"Alpha-Bisabolol suppresses the inflammatory response and ECM catabolism in advanced glycation end products-treated chondrocytes and attenuates murine osteoarthritis","volume":"84","author":"C. Xu","year":"2020","journal-title":"International Immunopharmacology"},{"issue":"1","key":"49","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/jcp.26769","article-title":"Andrographolide protects chondrocytes from oxidative stress injury by activation of the Keap1-Nrf2-Are signaling pathway","volume":"234","author":"B. Li","year":"2018","journal-title":"Journal of Cellular Physiology"},{"issue":"1","key":"50","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10787-018-00554-5","article-title":"Proteoglycans isolated from the bramble shark cartilage show potential anti-osteoarthritic properties","volume":"27","author":"K. K. Ajeeshkumar","year":"2019","journal-title":"Inflammopharmacology"},{"issue":"4","key":"51","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1007\/s00776-015-0718-4","article-title":"Gallic acid can play a chondroprotective role against AGE-induced osteoarthritis progression","volume":"20","author":"L. Wen","year":"2015","journal-title":"Journal of Orthopaedic Science"},{"issue":"26","key":"52","doi-asserted-by":"crossref","first-page":"41988","DOI":"10.18632\/oncotarget.16716","article-title":"Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway","volume":"8","author":"E. X. Xue","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"53","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.3892\/mmr.2017.6904","article-title":"Baicalin prevents the apoptosis of endplate chondrocytes by inhibiting the oxidative stress induced by H2O2","volume":"16","author":"Y. Pan","year":"2017","journal-title":"Molecular Medicine Reports"},{"issue":"3","key":"54","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.knee.2020.03.005","article-title":"The effect of kaempferol and apigenin on allogenic synovial membrane-derived stem cells therapy in knee osteoarthritic male rats","volume":"27","author":"F. Estakhri","year":"2020","journal-title":"The Knee"},{"issue":"6","key":"55","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1111\/jcmm.14333","article-title":"Isorhamnetin attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through modulating reactive oxygen species homeostasis","volume":"23","author":"F. Zhou","year":"2019","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"56","doi-asserted-by":"crossref","first-page":"9177","DOI":"10.12659\/MSM.913726","article-title":"Effects of hesperidin on H(2)O(2)-treated chondrocytes and cartilage in a rat osteoarthritis model","volume":"24","author":"G. Gao","year":"2018","journal-title":"Medical Science Monitor"},{"issue":"9","key":"57","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1002\/jcb.27051","article-title":"Ligustrazine protects chondrocyte against IL-1beta induced injury by regulation of SOX9\/NF-kappaB signaling pathway","volume":"119","author":"T. Yu","year":"2018","journal-title":"Journal of Cellular Biochemistry"},{"key":"58","article-title":"Hederacoside-C protects against AGEs-induced ECM degradation in mice chondrocytes","volume":"84","author":"H. C. Xu","year":"2020","journal-title":"International Immunopharmacology"},{"key":"59","article-title":"Cytoprotective effects of delphinidin for human chondrocytes against oxidative stress through activation of autophagy","volume":"9","author":"D. Y. Lee","year":"2020","journal-title":"Antioxidants"},{"issue":"11","key":"60","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1039\/C7FO00822H","article-title":"Piceatannol inhibits the IL-1beta-induced inflammatory response in human osteoarthritic chondrocytes and ameliorates osteoarthritis in mice by activating Nrf2","volume":"8","author":"Q. Tang","year":"2020","journal-title":"Food and Function"},{"issue":"2","key":"61","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4049\/jimmunol.1801513","article-title":"Nicotine attenuates osteoarthritis pain and matrix metalloproteinase-9 expression via the alpha7 nicotinic acetylcholine receptor","volume":"203","author":"P. Teng","year":"2019","journal-title":"The Journal of Immunology"},{"issue":"2","key":"62","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/jcmm.12186","article-title":"Berberine ameliorates cartilage degeneration in interleukin-1beta-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling","volume":"18","author":"H. Zhao","year":"2014","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"63","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.biopha.2018.05.003","article-title":"Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK\/SIRT1 signaling pathway in OA rats","volume":"103","author":"L. Qiu","year":"2018","journal-title":"Biomedicine and Pharmacotherapy"},{"issue":"3","key":"64","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/ddr.21510","article-title":"Protective effects of quercetin against inflammation and oxidative stress in a rabbit model of knee osteoarthritis","volume":"80","author":"B. Wei","year":"2019","journal-title":"Drug Development Research"},{"issue":"1","key":"65","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/japtr.JAPTR_331_18","article-title":"Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats","volume":"10","author":"D. A. Permatasari","year":"2019","journal-title":"Journal of Advanced Pharmaceutical Technology and Research"},{"key":"66","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.intimp.2017.09.017","article-title":"Baicalin suppresses IL-1beta-induced expression of inflammatory cytokines via blocking NF-kappaB in human osteoarthritis chondrocytes and shows protective effect in mice osteoarthritis models","volume":"52","author":"C. Chen","year":"2017","journal-title":"International Immunopharmacology"},{"issue":"2","key":"67","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.intimp.2014.10.007","article-title":"Monotropein exerts protective effects against IL-1beta-induced apoptosis and catabolic responses on osteoarthritis chondrocytes","volume":"23","author":"F. Wang","year":"2014","journal-title":"International Immunopharmacology"},{"issue":"1","key":"68","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/iub.1343","article-title":"Pinocembrin inhibits matrix metalloproteinase expression in chondrocytes","volume":"67","author":"D. Zhang","year":"2015","journal-title":"IUBMB Life"},{"key":"69","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1186\/1472-6882-14-444","article-title":"Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies","volume":"14","author":"D. Q. Wu","year":"2014","journal-title":"BMC Complementary and Alternative Medicine"},{"issue":"8","key":"70","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1248\/bpb.b15-00198","article-title":"Biological effects of the herbal plant-derived phytoestrogen bavachin in primary rat chondrocytes","volume":"38","author":"G. J. Lee","year":"2015","journal-title":"Biological and Pharmaceutical Bulletin"},{"issue":"1","key":"71","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.intimp.2013.11.021","article-title":"Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model","volume":"18","author":"L. Zeng","year":"2014","journal-title":"International Immunopharmacology"},{"key":"72","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jep.2015.06.031","article-title":"Gentiopicroside prevents interleukin-1 beta induced inflammation response in rat articular chondrocyte","volume":"172","author":"L. Zhao","year":"2015","journal-title":"Journal of Ethnopharmacology"},{"key":"73","article-title":"Chondroprotective effects of ginsenoside Rg1 in human osteoarthritis chondrocytes and a rat model of anterior cruciate ligament transection","volume":"9","author":"W. Cheng","year":"2017","journal-title":"Nutrients"},{"issue":"9","key":"74","article-title":"Gypenoside inhibits interleukin-1beta-induced inflammatory response in human osteoarthritis chondrocytes","volume":"31","author":"Z. H. Wan","year":"2017","journal-title":"Journal of Biochemical and Molecular Toxicology"},{"issue":"2","key":"75","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s10753-016-0309-3","article-title":"Tenuigenin prevents IL-1beta-induced inflammation in human osteoarthritis chondrocytes by suppressing PI3K\/AKT\/NF-kappaB signaling pathway","volume":"39","author":"C. Wang","year":"2016","journal-title":"Inflammation"},{"key":"76","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fphar.2019.00041","article-title":"Schisandrin A inhibits the IL-1beta-induced inflammation and cartilage degradation via suppression of MAPK and NF-kappaB signal pathways in rat chondrocytes","volume":"10","author":"C. Tu","year":"2019","journal-title":"Frontiers in Pharmacology"},{"issue":"5","key":"77","doi-asserted-by":"crossref","first-page":"768","DOI":"10.3109\/14397595.2015.1008724","article-title":"Astaxanthin ameliorates cartilage damage in experimental osteoarthritis","volume":"25","author":"L. J. Huang","year":"2015","journal-title":"Modern Rheumatology"},{"key":"78","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.2147\/DDDT.S216596","article-title":"Tanshinone I inhibits IL-1beta-induced apoptosis, inflammation and extracellular matrix degradation in chondrocytes CHON-001 cells and attenuates murine osteoarthritis","volume":"13","author":"X. Wang","year":"2019","journal-title":"Drug Design, Development and Therapy"},{"issue":"2","key":"79","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.intimp.2015.09.014","article-title":"Shikonin inhibits inflammatory responses in rabbit chondrocytes and shows chondroprotection in osteoarthritic rabbit knee","volume":"29","author":"F. Li","year":"2015","journal-title":"International Immunopharmacology"},{"issue":"1","key":"80","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11626-011-9475-7","article-title":"Polyoxypregnane glycoside from Dregea volubilis extract inhibits IL-1beta-induced expression of matrix metalloproteinase via activation of NF-kappaB in human chondrocytes","volume":"48","author":"A. Itthiarbha","year":"2012","journal-title":"In Vitro Cellular & Developmental Biology Animal"},{"issue":"1","key":"81","doi-asserted-by":"crossref","first-page":"229","DOI":"10.7150\/ijbs.28830","article-title":"Psoralen protects chondrocytes, exhibits anti-inflammatory effects on synoviocytes, and attenuates monosodium iodoacetate-induced osteoarthritis","volume":"15","author":"C. Wang","year":"2019","journal-title":"International Journal of Biological Sciences"},{"issue":"2","key":"82","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.bbrc.2019.12.065","article-title":"Chondrocytes-derived exosomal miR-8485 regulated the Wnt\/beta-catenin pathways to promote chondrogenic differentiation of BMSCs","volume":"523","author":"Z. Li","year":"2019","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"83","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.2147\/DDDT.S210220","article-title":"Aucubin protects chondrocytes against IL-1beta-induced apoptosis in vitro and inhibits osteoarthritis in mice model","volume":"13","author":"B. W. Wang","year":"2019","journal-title":"Drug Design, Development and Therapy"},{"issue":"4","key":"84","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00011-020-01327-z","article-title":"Chondro-protective effects of celastrol on osteoarthritis through autophagy activation and NF-kappaB signaling pathway inhibition","volume":"69","author":"K. Feng","year":"2020","journal-title":"Inflammation Research"},{"issue":"3","key":"85","first-page":"2343","article-title":"Therapeutic effect of Resveratrol in the treatment of osteoarthritis via the MALAT1\/miR-9\/NF-kappaB signaling pathway","volume":"19","author":"G. Zhang","year":"2020","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"6","key":"86","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1002\/jcb.26682","article-title":"Achyranthes bidentata polysaccharide suppresses osteoclastogenesis and bone resorption via inhibiting RANKL signaling","volume":"119","author":"D. Song","year":"2018","journal-title":"Journal of Cellular Biochemistry"},{"issue":"4","key":"87","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3892\/ijmm.2014.1869","article-title":"Achyranthes bidentata polysaccharides activate the Wnt\/beta-catenin signaling pathway to promote chondrocyte proliferation","volume":"34","author":"X. Weng","year":"2014","journal-title":"International Journal of Molecular Medicine"},{"issue":"5","key":"88","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.3892\/mmr.2017.6412","article-title":"Cibotium barometz polysaccharides stimulate chondrocyte proliferation in vitro by promoting G1\/S cell cycle transition","volume":"15","author":"C. Fu","year":"2017","journal-title":"Molecular Medicine Reports"},{"issue":"4","key":"89","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.bbrc.2016.04.064","article-title":"Rutin protects rat articular chondrocytes against oxidative stress induced by hydrogen peroxide through SIRT1 activation","volume":"473","author":"J. Y. Na","year":"2016","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"3","key":"90","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.3892\/mmr.2017.6980","article-title":"Astragaloside IV protects against apoptosis in human degenerative chondrocytes through autophagy activation","volume":"16","author":"J. Liu","year":"2017","journal-title":"Molecular Medicine Reports"},{"key":"91","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejphar.2016.07.027","article-title":"Berberine promotes proliferation of sodium nitroprusside-stimulated rat chondrocytes and osteoarthritic rat cartilage via Wnt\/beta-catenin pathway","volume":"789","author":"Y. Zhou","year":"2016","journal-title":"European Journal of Pharmacology"},{"issue":"3","key":"92","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.bbrc.2012.06.045","article-title":"Requirement of the phosphatidylinositol 3-kinase\/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis","volume":"423","author":"X. Zheng","year":"2012","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"2","key":"93","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.kjms.2016.11.004","article-title":"Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1beta-induced inflammation and apoptosis in vitro","volume":"33","author":"X. X. Xu","year":"2017","journal-title":"The Kaohsiung Journal of Medical Sciences"},{"issue":"5","key":"94","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3892\/ijmm.2017.3148","article-title":"Psoralen promotes the expression of cyclin D1 in chondrocytes via the Wnt\/beta-catenin signaling pathway","volume":"40","author":"W. Zheng","year":"2017","journal-title":"International Journal of Molecular Medicine"},{"issue":"8","key":"95","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.joca.2018.04.018","article-title":"Defining the osteoarthritis patient: back to the future","volume":"26","author":"G. P. Dobson","year":"2018","journal-title":"Osteoarthritis and Cartilage"},{"issue":"3","key":"96","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.joca.2017.11.014","article-title":"Osteoarthritis year in review 2017: clinical","volume":"26","author":"A. E. Nelson","year":"2018","journal-title":"Osteoarthritis and Cartilage"},{"issue":"2","key":"97","first-page":"127","article-title":"Non-surgical treatment of knee osteoarthritis","volume":"25","author":"H. S. Kan","year":"2019","journal-title":"Hong Kong Medical Journal"},{"issue":"1","key":"98","first-page":"11","article-title":"Paracetamol: mechanism of action, applications and safety concern","volume":"71","author":"M. J\u00f3\u017awiak-Bebenista","year":"2014","journal-title":"Acta Poloniae Pharmaceutica"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019723"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.3390\/medicines7110067"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/7714533.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/7714533.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/7714533.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T21:29:33Z","timestamp":1633037373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/7714533\/"}},"subtitle":[],"editor":[{"given":"Antonella","family":"Fioravanti","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,30]]},"references-count":100,"alternative-id":["7714533","7714533"],"URL":"https:\/\/doi.org\/10.1155\/2021\/7714533","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,30]]}}}