{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:59:31Z","timestamp":1789747171074,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":262,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. We aimed to summarize the current evidence regarding the impact of extraction vs. nonextraction in orthodontic treatment on patients\u2019 soft\u2010tissue profile with malocclusion. <jats:italic>Methods<\/jats:italic>. Between April 30<jats:sup>th<\/jats:sup> and November 30<jats:sup>th<\/jats:sup>, 2020, we searched PubMed and SCOPUS for published papers from inception to November 2020 using \u201corthodontic,\u201d \u201cextraction,\u201d \u201cnonextraction,\u201d and \u201cMalocclusion.\u201d Included studies were summarized, and relevant data were extracted and analyzed using Review Manager 5.4. <jats:italic>Results<\/jats:italic>. Pooled data from four controlled trials demonstrated a nonsignificant difference between extraction and nonextraction in terms of SNA (MD = 0.50, 95% CI: \u20100.37, 1.38; <jats:italic>p<\/jats:italic> = 0.26), SNB (MD = 0.11, 95% CI: \u20101.23, 1.44; <jats:italic>p<\/jats:italic> = 0.88), FMA (MD = 1.82, 95% CI: \u20102.39, 6.02; <jats:italic>p<\/jats:italic> = 0.40), IMPA (MD = 0.06, 95% CI: \u20108.83, \u20108.94; <jats:italic>p<\/jats:italic> = 0.99), overjet (MD = \u22121.47, 95% CI: \u20106.21, 3.26; <jats:italic>p<\/jats:italic> = 0.54), and overbite (MD = 0.50, 95% CI: \u20101.40, 2.40; <jats:italic>p<\/jats:italic> = 0.60). On the other hand, the extraction method significantly increased the ANB compared with the nonextraction group (MD = 0.78, 95% CI: 0.25, 1.31; <jats:italic>p<\/jats:italic> = 0.004). <jats:italic>Conclusion<\/jats:italic>. The current evidence demonstrated that nonextraction protocols for orthodontic treatment are a safe and effective alternative to extraction protocols; individually tailored treatment strategies should be applied. More randomized controlled trials are critically needed to safely make an evidence\u2010based treatment conclusion.<\/jats:p>","DOI":"10.1155\/2021\/7751516","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T18:20:31Z","timestamp":1632162031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Extraction vs. Nonextraction on Soft\u2010Tissue Profile Change in Patients with Malocclusion: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2021","author":[{"given":"SangYoun","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6005-0865","authenticated-orcid":false,"given":"Abdelrahman Magdi Ahmd","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YaLi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenJie","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7237-451X","authenticated-orcid":false,"given":"Chen","family":"Yaosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-1867","authenticated-orcid":false,"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjn125"},{"key":"e_1_2_11_2_2","unstructured":"ProffitW. 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