{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:28:26Z","timestamp":1783002506702,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Plan Project of Yichang City","award":["A19-301-32"],"award-info":[{"award-number":["A19-301-32"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2021,10,16]]},"abstract":"<jats:p>Objective. To develop and validate a prediction model for high ovarian response in in vitro fertilization-embryo transfer (IVF-ET) cycles. Methods. Totally, 480 eligible outpatients with infertility who underwent IVF-ET were selected and randomly divided into the training set for developing the prediction model and the testing set for validating the model. Univariate and multivariate logistic regressions were carried out to explore the predictive factors of high ovarian response, and then, the prediction model was constructed. Nomogram was plotted for visualizing the model. Area under the receiver-operating characteristic (ROC) curve, Hosmer-Lemeshow test and calibration curve were used to evaluate the performance of the prediction model. Results. Antral follicle count (AFC), anti-M\u00fcllerian hormone (AMH) at menstrual cycle day 3 (MC3), and progesterone (P) level on human chorionic gonadotropin (HCG) day were identified as the independent predictors of high ovarian response. The value of area under the curve (AUC) for our multivariate model reached 0.958 (95% CI: 0.936-0.981) with the sensitivity of 0.916 (95% CI: 0.863-0.953) and the specificity of 0.911 (95% CI: 0.858-0.949), suggesting the good discrimination of the prediction model. The Hosmer-Lemeshow test and the calibration curve both suggested model\u2019s good calibration. Conclusion. The developed prediction model had good discrimination and accuracy via internal validation, which could help clinicians efficiently identify patients with high ovarian response, thereby improving the pregnancy rates and clinical outcomes in IVF-ET cycles. However, the conclusion needs to be confirmed by more related studies.<\/jats:p>","DOI":"10.1155\/2021\/7822119","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T17:06:07Z","timestamp":1634403967000},"page":"1-12","source":"Crossref","is-referenced-by-count":7,"title":["Development and Validation of Prediction Model for High Ovarian Response in In Vitro Fertilization-Embryo Transfer: A Longitudinal Study"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0354-0056","authenticated-orcid":true,"given":"Xinsha","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Reproductive Medical Center, Affiliated Renhe Hospital of China Three Gorges University, Yichang 443002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medical Center, Affiliated Renhe Hospital of China Three Gorges University, Yichang 443002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-0772","authenticated-orcid":true,"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0248-5625","authenticated-orcid":true,"given":"Wenfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Science, Shanghai Institute of Technology, Shanghai 201418, China"},{"name":"International Academy of Visual Art and Engineering, London E16 1AH, UK"},{"name":"Interscience Institute of Management and Technology, Bhubaneswar 752054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2016.43.4.228"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13305"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.02.027"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(17)30070-1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der106"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.14488"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01622-7"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml034"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00325"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2020.02.003"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012693.pub2"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.04.029"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0113-1"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006495"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1109\/TNNLS.2017.2716952"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq034"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.6.559"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-009-9319-5"},{"issue":"11","key":"19","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1210\/clinem\/dgaa513","article-title":"Anti-M\u00fcllerian hormone and ovarian reserve: update on assessing ovarian function","volume":"105","author":"L. 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