{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:09:21Z","timestamp":1740161361817,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["93-01-21\u20137461"],"award-info":[{"award-number":["93-01-21\u20137461"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pathogens"],"published-print":{"date-parts":[[2021,2,11]]},"abstract":"<jats:p>Background. Bambusa vulgaris (Tabashir) has been shown to have antimicrobial, antioxidant, and anti-inflammatory effects due to the presence of ascorbic acid, vitamin B2, flavonoid, and phenolic compounds which can be beneficial in the process of wound healing. The current study aimed to evaluate the effects of topical Tabashir extract on cutaneous leishmaniasis (CL) caused by Leishmania major in BALB\/c mice. Methods. Twenty-eight female BALB\/c mice (4 weeks old, 18\u2009\u00b1\u20094 grams) were injected subcutaneously in tail-base with L. major amastigotes. Treatment started when the CL lesions were appeared and continued for 21 days. Mice were then divided into four groups: E1, treated daily with 5% of Tabashir extract gel; E2, treated daily with 10% Tabashir gel; C1, irrigated daily only with normal saline; and C2, received vehicle gel daily. The wounds\u2019 sizes were measured every 3 days, using vernier caliper. The volume densities of vessels, collagens, and hair follicles, vessels\u2019 length density, and mean diameter were soteriologically determined. Results. Tabashir enhanced wound closure rate through increasing the number of fibroblasts, collagen bundles, and vessels, according to histomorphometric evaluation while it did not affect the parasitic load. Findings of the in vitro study revealed that the extract has substantial mortality for the Leishmania promastigotes. Conclusion. Topical Tabashir showed promising effects on the healing process of skin wounds caused by CL in this experimental study. Further studies are suggested to find out the molecules which are involved in the healing process.<\/jats:p>","DOI":"10.1155\/2021\/7860474","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:46:33Z","timestamp":1613090793000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["Topical Bambusa vulgaris Extract Enhances Wound Healing in Cutaneous Leishmaniasis"],"prefix":"10.1155","volume":"2021","author":[{"given":"Zahra","family":"Ghanbarinasab","sequence":"first","affiliation":[{"name":"Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnaz","family":"Hosseini-Bensenjan","sequence":"additional","affiliation":[{"name":"Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-0166","authenticated-orcid":true,"given":"Elaheh Ziaei","family":"Ziabari","sequence":"additional","affiliation":[{"name":"The Rothman Institute, Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiva","family":"Aminnia","sequence":"additional","affiliation":[{"name":"Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roham","family":"Borazjani","sequence":"additional","affiliation":[{"name":"Trauma Research Center,  Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Rastegarian Jahromi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qasem","family":"Asgari","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-9057","authenticated-orcid":true,"given":"Bahador","family":"Sarkari","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2299-6278","authenticated-orcid":true,"given":"Soheil","family":"Ashkani-Esfahani","sequence":"additional","affiliation":[{"name":"Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)31204-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/qco.0000000000000194"},{"volume-title":"Leishmaniasis Fact Sheet","year":"2016","author":"World Health Organization","key":"3"},{"key":"4","first-page":"5030","article-title":"Proximate analysis and antimicrobial activities of Bambusa vulgaris L. leaves\u2019 beverage","volume":"6","author":"I. Owokotomo","year":"2011","journal-title":"African Journal of Agricultural Research"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2015.07.001"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2016.06.004"},{"key":"7","first-page":"436","article-title":"Bambusa vulgaris Schrad. ex JC Wendl. var. vittata Riviere & C. Riviere leaves attenuate oxidative stress-An in vitro biochemical assay","volume":"4","author":"A. K. Goyal","year":"2013","journal-title":"Indian Journal of Natural Products and Resources"},{"volume-title":"Antidiabetic Plants in India and Herbal Based Antidiabetic Research","year":"2003","author":"T. Pullaiah","key":"8"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1039\/c5ra02669e"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001141"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-8206.2003.00168.x"},{"key":"12","first-page":"21","article-title":"Effect of hydroalcoholic extract of Arnebia euchroma on the treatment of cutaneous leishmaniasis","volume":"12","author":"R. Borazjani","year":"2018","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/2277-9175.142314","article-title":"Taurine improves the wound healing process in cutaneous leishmaniasis in mice model, based on stereological parameters","volume":"3","author":"S. Ashkani-Esfahani","year":"2014","journal-title":"Advanced Biomedical Research"},{"key":"14","article-title":"In vivo assay of wound healing activities of Silymarin extract on cutaneous wounds caused by leishmania major","volume":"20","author":"M. Rastegarian","year":"2018","journal-title":"Shiraz E-Medical Journal"},{"key":"15","first-page":"312","article-title":"Iranian native plants on treatment of cutaneous leishmaniosis: a narrative review","volume":"12","author":"E. Moghaddas","year":"2017","journal-title":"Iranian Journal of Parasitology"}],"container-title":["Journal of Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpath\/2021\/7860474.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpath\/2021\/7860474.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpath\/2021\/7860474.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:46:40Z","timestamp":1613090800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jpath\/2021\/7860474\/"}},"subtitle":[],"editor":[{"given":"Mario M.","family":"D\u2019Elios","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,2,11]]},"references-count":15,"alternative-id":["7860474","7860474"],"URL":"https:\/\/doi.org\/10.1155\/2021\/7860474","relation":{},"ISSN":["2090-3065","2090-3057"],"issn-type":[{"type":"electronic","value":"2090-3065"},{"type":"print","value":"2090-3057"}],"subject":[],"published":{"date-parts":[[2021,2,11]]}}}