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Together with the acknowledged angiotensin\u2010converting enzyme 2, glucose\u2010regulated protein 78, transferrin receptor, AXL, kidney injury molecule\u20101, and neuropilin 1 are also identified as potential receptors to mediate SARS\u2010CoV\u20102 infection. Therefore, how to inhibit or delay the binding of SARS\u2010CoV\u20102 with the abovementioned receptors is a key step for the prevention and treatment of COVID\u201019. As the third gasotransmitter, hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) plays an important role in many physiological and pathophysiological processes. Recently, survivors were reported to have significantly higher H<jats:sub>2<\/jats:sub>S levels in COVID\u201019 patients, and mortality was significantly greater among patients with decreased H<jats:sub>2<\/jats:sub>S levels. 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