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Herbal medicines and refined natural products have resources for the development of novel antiviral drugs. These natural agents have shed light on preventive vaccine development and antiviral therapies. This review intends to discuss the antiviral activities of plant extracts and some isolated plant natural products based on mainly preclinical (in vitro and in vivo) studies. Twenty medicinal herbs were selected for the discussion, and those are commonly recognized antiviral medicinal plants in Ayurveda (<jats:italic>Zingiber officinale<\/jats:italic>, <jats:italic>Caesalpinia bonducella<\/jats:italic>, <jats:italic>Allium sativum<\/jats:italic>, <jats:italic>Glycyrrhiza glabra<\/jats:italic>, <jats:italic>Ferula assafoetida<\/jats:italic>, <jats:italic>Gymnema sylvestre<\/jats:italic>, <jats:italic>Gossypium herbaceum<\/jats:italic>, <jats:italic>Phyllanthus niruri<\/jats:italic>, <jats:italic>Trachyspermum ammi<\/jats:italic>, <jats:italic>Withania somnifera<\/jats:italic>, <jats:italic>Andrographis paniculata<\/jats:italic>, <jats:italic>Centella asiatica<\/jats:italic>, <jats:italic>Curcuma longa<\/jats:italic>, <jats:italic>Woodfordia fruticose<\/jats:italic>, <jats:italic>Phyllanthus emblica<\/jats:italic>, <jats:italic>Terminalia chebula<\/jats:italic>, <jats:italic>Tamarindus indica<\/jats:italic>, <jats:italic>Terminalia arjuna<\/jats:italic>, <jats:italic>Azadirachta indica<\/jats:italic>, and <jats:italic>Ficus religiosa)<\/jats:italic>. However, many viruses remain without successful immunization and only a few antiviral drugs have been approved for clinical use. Hence, the development of novel antiviral drugs is much significant and natural products are excellent sources for such drug developments. In this review, we summarize the antiviral actions of selected plant extracts and some isolated natural products of the medicinal herbs.<\/jats:p>","DOI":"10.1155\/2021\/7872406","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T23:20:25Z","timestamp":1639005625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Antiviral Potential of Selected Medicinal Herbs and Their Isolated Natural Products"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-6579","authenticated-orcid":false,"given":"W. P. R. 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