{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:03:26Z","timestamp":1784919806213,"version":"3.55.0"},"reference-count":114,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":277,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>COVID\u201019\u2010associated neuropsychiatric complications are soaring. There is an urgent need to understand the link between COVID\u201019 and neuropsychiatric disorders. To that end, this article addresses the premise that SARS\u2010CoV\u20102 infection results in gut dysbiosis and an altered microbiota\u2010gut\u2010brain (MGB) axis that in turn contributes to the neuropsychiatric ramifications of COVID\u201019. Altered MGB axis activity has been implicated independently as a risk of neuropsychiatric disorders. A review of the changes in gut microbiota composition in individual psychiatric and neurological disorders and gut microbiota in COVID\u201019 patients revealed a shared \u201cmicrobial signature\u201d characterized by a lower microbial diversity and richness and a decrease in health\u2010promoting anti\u2010inflammatory commensal bacteria accompanied by an increase in opportunistic proinflammatory pathogens. Notably, there was a decrease in short\u2010chain fatty acid (SCFA) producing bacteria. SCFAs are key bioactive microbial metabolites with anti\u2010inflammatory functions and have been recognized as a critical signaling pathway in the MGB axis. SCFA deficiency is associated with brain inflammation, considered a cardinal feature of neuropsychiatric disorders. The link between SARS\u2010CoV\u20102 infection, gut dysbiosis, and altered MGB axis is further supported by COVID\u201019\u2010associated gastrointestinal symptoms, a high number of SARS\u2010CoV\u20102 receptors, angiotensin\u2010cleaving enzyme\u20102 (ACE\u20102) in the gut, and viral presence in the fecal matter. The binding of SARS\u2010CoV\u20102 to the receptor results in ACE\u20102 deficiency that leads to decreased transport of vital dietary components, gut dysbiosis, proinflammatory gut status, increased permeability of the gut\u2010blood barrier (GBB), and systemic inflammation. More clinical research is needed to substantiate further the linkages described above and evaluate the potential significance of gut microbiota as a diagnostic tool. Meanwhile, it is prudent to propose changes in dietary recommendations in favor of a high fiber diet or supplementation with SCFAs or probiotics to prevent or alleviate the neuropsychiatric ramifications of COVID\u201019.<\/jats:p>","DOI":"10.1155\/2021\/7880448","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T16:56:07Z","timestamp":1633452967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Neuropsychiatric Ramifications of COVID\u201019: Short\u2010Chain Fatty Acid Deficiency and Disturbance of Microbiota\u2010Gut\u2010Brain Axis Signaling"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5821-2493","authenticated-orcid":false,"given":"Elizabeth 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