{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:43:36Z","timestamp":1789670616010,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017022","name":"Ministry of Health of the Republic of Indonesia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100017022","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2021,3,30]]},"abstract":"<jats:p>Neem (Azadirachta indica A. Juss) is one of the tropical plants found in Indonesia that has been used to prevent and treat various diseases. This study aimed to investigate the effect of the ethanol extract of neem leaves on the concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine in male rats. Twenty-four male Wistar rats were randomly divided into four groups (T0, T1, T2, and T3) with 6 rats in each group. T0 is the control group, and T1, T2, and T3 are the treatment groups that were administered 100, 200, and 300\u2009mg\/kg body weight of neem leaf ethanolic extracts for 48 days, respectively. On day 49, blood samples were collected to measure the concentration of AST, ALT, creatinine, and urea followed by an evaluation of liver and kidney histology. The results showed that the ethanolic extract of neem leaves did not affect the concentration of AST, ALT, and creatinine, The ethanol leaves reduced extract on the urea concentration, no abnormal changes were observed in the liver and kidney organs. In the future, it is required to carry out a comprehensive safety evaluation of the neem leaf ethanol extract for herbal medicines.<\/jats:p>","DOI":"10.1155\/2021\/7970424","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T19:20:09Z","timestamp":1617218409000},"page":"1-7","source":"Crossref","is-referenced-by-count":27,"title":["Neem Leaf (Azadirachta indica A. Juss) Ethanolic Extract on the Liver and Kidney Function of Rats"],"prefix":"10.1155","volume":"2021","author":[{"given":"Irma","family":"Seriana","sequence":"first","affiliation":[{"name":"Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"},{"name":"Department of Midwifery, Polytechnic of Health, Ministry of Health, Aceh Besar 23231, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-1505","authenticated-orcid":true,"given":"Muslim","family":"Akmal","sequence":"additional","affiliation":[{"name":"Laboratory of Histology, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darusman","family":"Darusman","sequence":"additional","affiliation":[{"name":"Soil Science Department, Faculty of Agriculture, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri","family":"Wahyuni","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairan","family":"Khairan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"},{"name":"Herbal Medicinal Research Centre, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"},{"name":"Atsiri Research Centre, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugito","family":"Sugito","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21050559"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-74210-6_8"},{"key":"3","first-page":"1","article-title":"Plants in traditional medicinal system future source of new drugs","volume":"1","author":"S. 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