{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:43:02Z","timestamp":1747190582740,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Otolaryngology"],"published-print":{"date-parts":[[2021,12,24]]},"abstract":"<jats:p>Purpose. To explore outcomes of endolymphatic sac surgery for patients with Meniere\u2019s disease with and without the comorbid condition of migraine. Materials and Methods. A retrospective chart review of adult patients undergoing endolymphatic sac surgery at a single tertiary care center from 1987 to 2019 was performed. All adult patients who failed medical therapy and underwent primary endolymphatic sac surgery were included. The main outcome measures were vertigo control and functional level scale (FLS) score. Patient characteristics, comorbidities, and audiometric outcomes were tracked as well. Results. Patients with Meniere\u2019s disease and migraine had a stronger association with psychiatric comorbidities (64.29% vs. 25.80%, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.01<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>), shorter duration of vertigo episodes (143 vs. 393\u2009min, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.02<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), and younger age (36.6 vs. 50.8\u2009yr, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.005<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) at the time of endolymphatic sac surgery. Postoperative pure tone averages and word recognition scores were nearly identical to preoperative baselines. Class A vertigo control (47.92%) was most common, followed by class B vertigo control (31.25%). The FLS score improved from 4.2 to 2.8 (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Both patients with and without migraine had classes A-B vertigo control (66.67% vs. 80.95%) without any statistically significant difference (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.59<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). Of the patients who required secondary treatment (10.42%), none had migraine. Conclusions. Endolymphatic sac surgery is an effective surgical intervention for Meniere\u2019s disease with and without migraine. Patients with comorbid migraine tend to be younger and present with psychiatric comorbidities.<\/jats:p>","DOI":"10.1155\/2021\/7987851","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T21:35:09Z","timestamp":1640381709000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Endolymphatic Sac Surgery for Meniere\u2019s Disease with and without Comorbid Migraine"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-2203","authenticated-orcid":true,"given":"Norman A.","family":"Orabi","sequence":"first","affiliation":[{"name":"West Virginia University School of Medicine Department of Otolaryngology, P.O. Box 9200, Morgantown, WV 26506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7089-4658","authenticated-orcid":true,"given":"Brian M.","family":"Kellermeyer","sequence":"additional","affiliation":[{"name":"West Virginia University School of Medicine Department of Otolaryngology, P.O. Box 9200, Morgantown, WV 26506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2461-4931","authenticated-orcid":true,"given":"Christopher A.","family":"Roberts","sequence":"additional","affiliation":[{"name":"West Virginia University School of Medicine Department of Otolaryngology, P.O. Box 9200, Morgantown, WV 26506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3194-0807","authenticated-orcid":true,"given":"Stephen J.","family":"Wetmore","sequence":"additional","affiliation":[{"name":"West Virginia University School of Medicine Department of Otolaryngology, P.O. Box 9200, Morgantown, WV 26506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-7559","authenticated-orcid":true,"given":"Adam M.","family":"Cassis","sequence":"additional","affiliation":[{"name":"Arizona Hearing & Balance Center, 225 S Dobson Rd#1, Chandler, AZ 85224, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1159\/000286213"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820909438"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12844"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00182"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.05.014"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.11.1144"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1017\/s0022215116009713"},{"key":"9","first-page":"415","article-title":"10-year review of endolymphatic sac surgery for intractable Meniere disease","volume":"39","author":"A. 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