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Tanshinone I (TsI), a flavonoid compound isolated from Salvia miltiorrhiza Bunge, has been reported to inhibit osteoclastic differentiation in vitro. This study aimed to investigate whether TsI can ameliorate SIONFH. Herein, SIONFH was induced by intraperitoneal injection of 20\u2009\u03bcg\/kg lipopolysaccharide every 24\u2009h for 2 days, followed by an intramuscular injection of 40\u2009mg\/kg methylprednisolone every 24\u2009h for 3 days. Four weeks after the final injection of methylprednisolone, the rats were intraperitoneally administrated with low-dose (5\u2009mg\/kg) and high-dose (10\u2009mg\/kg) TsI once daily for 4 weeks. Results showed that TsI significantly alleviated osteonecrotic lesions of the femoral heads as determined by micro-CT analysis. Furthermore, TsI increased alkaline phosphatase activity and expressions of osteoblastic markers including osteocalcin, type I collagen, osteopontin, and Runt-related transcription factor 2 and decreased tartrate-resistant acid phosphatase activity and expressions of osteoclastic markers including cathepsin K and acid phosphatase 5. TsI also reduced inflammatory response and oxidative stress and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway in the femoral heads. Taken together, our findings show that TsI can relieve SIONFH, indicating that it may be a candidate for preventing SIONFH.<\/jats:p>","DOI":"10.1155\/2021\/8002161","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T21:05:18Z","timestamp":1640984718000},"page":"1-11","source":"Crossref","is-referenced-by-count":14,"title":["Tanshinone I Mitigates Steroid-Induced Osteonecrosis of the Femoral Head and Activates the Nrf2 Signaling Pathway in Rats"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5905-9136","authenticated-orcid":true,"given":"Xilin","family":"Xu","sequence":"first","affiliation":[{"name":"The Third Department of Orthopedics and Traumatology, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 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