{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:46Z","timestamp":1787017726508,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Urology"],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"<jats:p>Giant cell urothelial carcinoma is a rare variant of bladder cancer recognized by the current World Health Organization classification of urologic tumours. It is an aggressive tumour with a poor prognosis that usually presents at an advanced stage. It is characterized histologically by pleomorphic giant cells. We discuss a case of giant cell urothelial carcinoma presenting at an early stage in a previously well 62-year-old woman. Histology showed a tumour comprising pancytokeratin positive bizarre mononuclear and multi-nuclear giant cells admixed with areas of conventional urothelial carcinoma and carcinoma in situ. Three-month follow-up cystoscopy and magnetic resonance imaging showed no evidence of recurrence or pelvic lymphadenopathy.<\/jats:p>","DOI":"10.1155\/2021\/8021947","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T13:50:11Z","timestamp":1626443411000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Giant Cell Urothelial Carcinoma of Bladder"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-1440","authenticated-orcid":true,"given":"Harshima Disvini","family":"Wijesinghe","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Colombo, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-8254","authenticated-orcid":true,"given":"Ajith","family":"Malalasekera","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, University of Colombo, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","volume-title":"WHO Classification of Tumours of the Urinary System and Male Genital Organs","author":"H. 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