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The aim of this study was to provide the first study to systematically analyze the efficacy and safety of PCSK9\u2010mAbs in the treatment of familial hypercholesterolemia (FH). <jats:italic>Methods<\/jats:italic>. A computer was used to search the electronic Cochrane Library, PubMed\/MEDLINE, and Embase databases for clinical trials using the following search terms: \u201cAMG 145\u201d, \u201cevolocumab\u201d, \u201cSAR236553\/REGN727\u201d, \u201calirocumab\u201d, \u201cRG7652\u201d, \u201cLY3015014\u201d, \u201cRN316\/bococizumab\u201d, \u201cPCSK9\u201d, and \u201cfamilial hypercholesterolemia\u201d up to November 2020. Study quality was assessed with the Cochrane Collaboration\u2019s tool, and publication bias was evaluated by a contour\u2010enhanced funnel plot and the Harbord modification of the Egger test. After obtaining the data, a meta\u2010analysis was performed using R software, version 4.0.3. <jats:italic>Results<\/jats:italic>. A meta\u2010analysis was performed on 7 clinical trials (926 total patients). The results showed that PCSK9\u2010mAbs reduced the LDL\u2010C level by the greatest margin, WMD \u221249.14%, 95% CI: \u221255.81 to \u221242.47%, on FH versus control groups. PCSK9\u2010mAbs also significantly reduced lipoprotein (a) (Lp (a)), total cholesterol (TC), triglycerides (TG), apolipoprotein\u2010B (Apo\u2010B), and non\u2010high\u2010density lipoprotein cholesterol (non\u2010HDL\u2010C) levels and increased HDL\u2010C and apolipoprotein\u2010A1 (Apo\u2010A1) levels of beneficial lipoproteins. Moreover, no significant difference was found between PCSK9\u2010mAbs treatment and placebo in common adverse events, serious events, and laboratory adverse events. <jats:italic>Conclusion<\/jats:italic>. PCSK9\u2010mAbs significantly decreased LDL\u2010C and other lipid levels with satisfactory safety and tolerability in FH treatment.<\/jats:p>","DOI":"10.1155\/2021\/8032978","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T15:50:06Z","timestamp":1635695406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["[Retracted] A Systematic Review and Meta\u2010Analysis of Therapeutic Efficacy and Safety of Alirocumab and Evolocumab on Familial Hypercholesterolemia"],"prefix":"10.1155","volume":"2021","author":[{"given":"Xiaoyue","family":"Ge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keke","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8421-1395","authenticated-orcid":false,"given":"Weifang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,31]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020701"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.310217"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00833"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0941"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht273"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2018.10.012"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.01.004"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv707"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2018.03.088"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00316-3"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-1309-2"},{"key":"e_1_2_8_12_2","volume-title":"Cochrane","author":"Higgins J. 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