{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:18:48Z","timestamp":1767165528152,"version":"build-2238731810"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2021,4,16]]},"abstract":"<jats:p>Thyroid cancer is a relatively common endocrine gland malignant tumor; if improper treatment, there will be a high risk of recurrence or metastasis, and abnormal sugar chain glycoprotein (TAP) has a close relationship with the development of the disease; therefore, the purpose of this article is to discuss abnormal sugar chain glycoprotein (TAP) as thyroid cancer curative effect evaluation and radiation and chemotherapy after surgery clinical significance. In this paper, 95 patients with thyroid cancer diagnosed in a hospital were selected as the study objects and treated as the observation group. The clinical and follow-up data of the observation group were retrospectively analyzed. Meanwhile, 55 healthy patients were randomly selected as the control group. TAP, squamous cell carcinoma antigen (SCC) level, and carcinoembryonic antigen (CEA) level were detected in peripheral blood of 95 patients with thyroid cancer before and after treatment. The short-term efficacy was evaluated by chest CT examination, and the changes of the three markers before and after treatment and the correlation with the short-term efficacy of the patients were compared. According to the results of testing, the TAP positive expression in patients before radiotherapy can better predict the recent curative effect has certain clinical value; before radiotherapy TAP positive expression rate was significantly higher than that of healthy people, TAP positive expression quantity decreased obviously after radiation treatment, and patients with a recent radiotherapy curative effect is good or bad and negatively correlated with the degree of TAP protein positive expression; TAP high protein in patients with recent poor radiation effects, prompt the factor can be predicted in the near future curative effect of the molecular markers, and can TAP level for clinicians provide certain reference for targeted therapy.<\/jats:p>","DOI":"10.1155\/2021\/8072126","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T15:20:16Z","timestamp":1618672816000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["TAP Test Image Dynamic Tracking Study after Thyroid Cancer Surgery and after Radiotherapy and Chemotherapy"],"prefix":"10.1155","volume":"2021","author":[{"given":"Changliang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Galactophore Surgery, Weifang People\u2019s Hospital, Shandong 261041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxue","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Galactophore Surgery, Weifang People\u2019s Hospital, Shandong 261041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Men","sequence":"additional","affiliation":[{"name":"Department of Galactophore Surgery, Weifang People\u2019s Hospital, Shandong 261041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[{"name":"Weifang Medical University, Shandong 261041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9784-5912","authenticated-orcid":true,"given":"Meili","family":"Chen","sequence":"additional","affiliation":[{"name":"Weifang Brain Hospital Emergency Department, Shandong 261041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.110"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0392"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29251"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2015.07.013"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1007-3969.2015.04.013"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.17.7187"},{"issue":"10","key":"7","first-page":"18528","article-title":"Tumor abnormal protein (TAP) examination contributes to primary diagnosis of bladder cancer","volume":"8","author":"L. 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