{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T20:40:20Z","timestamp":1774903220406,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2021,12,22]]},"abstract":"<jats:p>In order to investigate the diagnostic value of prenatal ultrasound parameters and signs of pouch and lower thoracic esophagus in the fetus with esophageal atresia (EA), the prenatal ultrasound data of 35 EA fetuses (observation group) confirmed by autopsy after induced labor or postnatal surgery and imaging examination in our hospital from May 2019 to May 2021 were retrospectively analyzed and compared with 35 normal postnatal fetuses (control group). General information and prenatal ultrasound parameters of the two groups, including head circumference (HC), abdominal circumference (AC), double parietal diameter (BPD), fetal body weight (EFW), and signs (small or unmanifested gastric vesicles, amniotic fluid, neck or upper chest pouch, lower chest esophagus not visible), were analyzed using logistic regression. The logistic multifactor regression model for EA diagnosis was established, and the diagnostic value for EA was analyzed. As a result, the HC, AC, and EFW of the observation group were lower than those of the control group, the gastric bubbles were small or not displayed, the amniotic fluid was more, and the signs of neck or upper chest pouch and lower chest esophagus were not visible in the observation group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Logistic regression analysis showed that decreased ultrasound parameters HC, AC, EFW, small or no gastric bubble, amniotic fluid, neck or upper chest pouch, and no visible signs of lower chest esophagus were all risk factors for EA (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). And in the prenatal ultrasound diagnostic model of EA was established, logistic <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mfenced open=\"(\" close=\")\">\n                           <e:mrow>\n                              <e:mi>P<\/e:mi>\n                           <\/e:mrow>\n                        <\/e:mfenced>\n                        <e:mo>=<\/e:mo>\n                        <e:mo>\u2212<\/e:mo>\n                        <e:mn>19.851<\/e:mn>\n                        <e:mo>+<\/e:mo>\n                        <e:mtext>HC<\/e:mtext>\n                        <e:mo>\u00d7<\/e:mo>\n                        <e:mn>0.384<\/e:mn>\n                        <e:mo>+<\/e:mo>\n                        <e:mtext>AC<\/e:mtext>\n                        <e:mo>\u00d7<\/e:mo>\n                        <e:mn>0.682<\/e:mn>\n                        <e:mo>+<\/e:mo>\n                        <e:mtext>EFW<\/e:mtext>\n                        <e:mo>\u00d7<\/e:mo>\n                        <e:mn>0.695<\/e:mn>\n                        <e:mo>+<\/e:mo>\n                        <e:mtext>small<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>or<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>no<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>gastric<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>vesicle<\/e:mtext>\n                        <e:mo>\u00d7<\/e:mo>\n                        <e:mn>3.747<\/e:mn>\n                        <e:mo>+<\/e:mo>\n                        <e:mtext>amniotic<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>fluid<\/e:mtext>\n                        <e:mo>\u00d7<\/e:mo>\n                        <e:mn>3.607<\/e:mn>\n                        <e:mo>+<\/e:mo>\n                        <e:mtext>cervical<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>or<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>upper<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>chest<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>sac<\/e:mtext>\n                        <e:mo>\u00d7<\/e:mo>\n                        <e:mn>4.104<\/e:mn>\n                        <e:mo>+<\/e:mo>\n                        <e:mtext>invisible<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>lower<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>thoracic<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>esophagus<\/e:mtext>\n                        <e:mo>\u00d7<\/e:mo>\n                        <e:mn>4.623<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>.When logistic <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <i:mfenced open=\"(\" close=\")\">\n                           <i:mrow>\n                              <i:mi>P<\/i:mi>\n                           <\/i:mrow>\n                        <\/i:mfenced>\n                        <i:mo>&gt;<\/i:mo>\n                        <i:mn>0.468<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, AUC was 0.891, <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <m:mi>\u03c7<\/m:mi>\n                        <m:mn>2<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula> was 7.764, diagnostic sensitivity was 91.24%, and specificity was 79.22%. To draw a conclusion, prenatal ultrasound parameters and signs are of great value in the diagnosis of EA. Independent influencing factors of EA include small or no HC, AC, EFW and gastric vesicles, polyhydramnios, neck or upper chest pouch, and invisible lower thoracic esophagus. Logistic multifactor regression model has a high coincidence rate for the prenatal diagnosis of EA, providing a basis for clinical decision-making.<\/jats:p>","DOI":"10.1155\/2021\/8107461","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T19:35:25Z","timestamp":1640201725000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic Value of Prenatal Ultrasound Parameters and Esophageal Signs in Pouch and Lower Thoracic Segment in Fetuses with Esophageal Atresia"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-4777","authenticated-orcid":true,"given":"Wenjun","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Hubei Women and Children\u2019s Hospital Attached by the Tongi Medical College, Huazhong Science and Technology University, Wuhan, Hubei 430070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2018.02.019"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0704-5"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jpedsurg.2020.07.028","article-title":"Esophageal substitution or esophageal elongation procedures in patients with complicated esophageal atresia? 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Chen","year":"2019","journal-title":"Journal of China Clinic Medical Imaging"},{"key":"8","volume-title":"UItrasonic Prenatal Diagnosis of Esophageal Atresia and a Correlated Study for Amniotic Fluid Biochemical Test of AFP and GGTP with Esophageal Atresia","author":"T. Li","year":"2017"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12342"},{"issue":"12","key":"10","first-page":"950","article-title":"Diagnostic value of flexible bronchoscopy in recurrent tracheoesophageal fistula after esophageal atresia repair","volume":"37","author":"L. Liang","year":"2019","journal-title":"Journal of Clinical Pediatrics"},{"issue":"2","key":"11","first-page":"117","article-title":"Application of permissive hypercapnia in thoracoscopic surgery of neonates with congenital esophageal; atresia","volume":"33","author":"W. Z. 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Huang","year":"2019","journal-title":"Chinese Journal of Perinatal Medicine"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.08.012"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-020-04829-3"},{"issue":"3","key":"22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jpedsurg.2020.05.045","article-title":"Validation of low-cost models for minimal invasive surgery training of congenital diaphragmatic hernia and esophageal atresia","volume":"56","author":"G. M. Bkkerink","year":"2021","journal-title":"Journal of Pediatric Surgery"},{"issue":"17","key":"23","first-page":"2956","article-title":"Comparison of extrapleural and transpleural approach in the treatment of type III congenital esophageal atresia","volume":"48","author":"J. S. 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An","year":"2019","journal-title":"Chinese Journal of Medical Imaging"}],"updated-by":[{"DOI":"10.1155\/2023\/9769848","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"record-id":"47893"},{"DOI":"10.1155\/2023\/9769848","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000}}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/8107461.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/8107461.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/8107461.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T19:35:49Z","timestamp":1640201749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2021\/8107461\/"}},"subtitle":[],"editor":[{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,12,22]]},"references-count":29,"alternative-id":["8107461","8107461"],"URL":"https:\/\/doi.org\/10.1155\/2021\/8107461","relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9769848","asserted-by":"object"}]},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,22]]}}}