{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:00:54Z","timestamp":1768352454433,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":290,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007119","name":"Yasuj University of Medical Sciences","doi-asserted-by":"publisher","award":["990005"],"award-info":[{"award-number":["990005"]}],"id":[{"id":"10.13039\/501100007119","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Herbal medicines harbor essential therapeutic agents for the treatment of cholestasis. In this study, we have assessed the anticholestatic potential of <jats:italic>Stachys pilifera Benth<\/jats:italic>\u2019s (SPB\u2019s) hydroalcoholic extract encapsulated into liposomes using bile duct ligation\u2010 (BDL\u2010) induced hepatic cholestasis in rats. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), malondialdehyde (MDA), total thiol (T\u2010SH) content, protein carbonyl (PCO), total bilirubin (TBIL), albumin (ALB), and nitric oxide (NO) metabolite levels were measured in either liver tissue or plasma to assess liver damage. Moreover, expression of proinflammatory cytokines (IL\u20101<jats:italic>\u03b2<\/jats:italic> and TNF\u2010<jats:italic>\u03b1<\/jats:italic>) and liver fibrosis markers (TGF\u2010<jats:italic>\u03b2<\/jats:italic> and SM\u2010<jats:italic>\u03b1<\/jats:italic>) which are driving forces of many liver disorders was also determined. The activity of AST, ALT, and ALP was significantly enhanced in the BDL group in comparison to the control group; however, treatment with liposomal (SPB) hydroalcoholic extract significantly reduced AST and ALT\u2019s activity. Increases in MDA, TBIL, and NO levels and T\u2010SH content due to BDL were restored to control levels by liposomal (SPB) hydroalcoholic extract treatment. Similarly, hepatic and plasma oxidative marker MDA levels, significantly enhanced by BDL, were significantly decreased by liposomal (SPB) hydroalcoholic extract treatment. Moreover, histopathological findings further demonstrated a significant decrease in hepatic damage in the liposomal (SPB) hydroalcoholic extract\u2010treated BDL group. In addition, liposomal (SPB) hydroalcoholic extract treatment decreased the liver expression of inflammatory cytokines (IL\u20101<jats:italic>\u03b2<\/jats:italic>, TNF\u2010<jats:italic>\u03b1<\/jats:italic>) and liver fibrosis markers (TGF\u2010<jats:italic>\u03b2<\/jats:italic> and SM\u2010<jats:italic>\u03b1<\/jats:italic>). Since liposomal (SPB) hydroalcoholic extract treatment alleviated the BDL\u2010induced injury of the liver and improved the hepatic structure and function more efficiently in comparison to free SPB hydroalcoholic extract, probable liposomal (SPB) hydroalcoholic extract exhibits required potential therapeutic value in protecting the liver against BDL\u2010caused oxidative injury.<\/jats:p>","DOI":"10.1155\/2021\/8141563","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T16:55:25Z","timestamp":1634662525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Liposome Extract of Stachys pilifera Benth Effectively Improved Liver Damage due to Bile Duct Ligation 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