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Chinese medicine decoctions, which have been used for centuries, are the most common form of traditional therapies. Objective. The purpose of the review was to evaluate the effectiveness and safety of Chinese medicine decoctions in the treatment of BD. Methods. Randomized controlled trials (RCTs) for BD treatment with Chinese medicine decoctions were searched in six electronic databases until March 2021. Primary outcomes were total effective rate, recovery rate, and recurrence rate. Secondary outcomes were clinical feature scores (oral ulcers, eye lesions, genital ulcers, skin lesions, arthropathies, fever, and pathergy reactions) and laboratory index levels (erythrocyte sedimentation rate, C-reactive protein, and immunoglobulin A). The risk of bias was assessed with the Cochrane Handbook, and a meta-analysis was performed with RevMan 5.4.1. Results. Sixteen RCTs with 924 patients were included in the review. The meta-analysis indicated that Chinese medicine decoctions were effective for BD when compared with control groups for all the primary outcomes and 7\/10 of the secondary outcomes. Adverse events were reported in 11 of the 16 RCTs, with the Chinese medicine decoctions possibly having fewer adverse events than western drugs. This review included a range of classical prescriptions. An additional meta-analysis of modified Gancao Xiexin Decoction for BD treatment was conducted. Gancao Xiexin decoction is also discussed as a representative prescription, as well as high-frequency herbs, and warrants further exploration for individualized medicine and pharmacology. Conclusion. Chinese medicine decoctions have the potential to be effective and safe for treating BD. However, additional well-designed RCTs are needed to confirm the findings because of the unsatisfactory quality of the included studies.<\/jats:p>","DOI":"10.1155\/2021\/8202512","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T17:05:07Z","timestamp":1626714307000},"page":"1-19","source":"Crossref","is-referenced-by-count":17,"title":["Effectiveness and Safety of Chinese Medicine Decoctions for Behcet\u2019s Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6541-9740","authenticated-orcid":true,"given":"Jingxian","family":"Yan","sequence":"first","affiliation":[{"name":"Chinese Medical College, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yan","sequence":"additional","affiliation":[{"name":"Xinglin College, Liaoning University of Traditional Chinese Medicine, Shenyang 110167, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Sciences, Arthur Dugoni School of Dentistry, University of the Pacific, Stockton, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3529-3283","authenticated-orcid":true,"given":"Zhiyong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Handan First Hospital, Handan 056000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0751-7374","authenticated-orcid":true,"given":"Zhimin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.02.011"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2016.1205486"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.208"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00665"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.12.006"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-019-02035-1"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1177319"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker151"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.09.002"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X20500780"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2174\/1872213X12666180115153635"},{"issue":"7","key":"12","first-page":"907","article-title":"Study of Behcet\u2019s disease: a review of recent literature","volume":"21","author":"M. 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