{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:56:08Z","timestamp":1759146968858,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273871"],"award-info":[{"award-number":["81273871"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Object.<\/jats:italic> Use a fluid\u2010structure interaction (FSI) model to do a safety risk assessment of cervical spinal manipulative therapy (cSMT) for atherosclerosis to study the biomechanical changes of atherosclerosis plaque and the carotid artery (CA) lumen during the process of cSMT. <jats:italic>Method<\/jats:italic>. The FSI model, based on MRI data of an atherosclerosis patient, was used to simulate the deformations of the plaque and lumen during the process of two kinds of typical cSMT (the high\u2010speed, low\u2010amplitude spinal manipulation and the cervical rotatory manipulation). The biomechanical parameters were recorded, such as the highest wall shear stress (WSS), the maximum plaque wall stress (PWS), the wall tensile stress (Von mises stress, VWTS), and the strain. <jats:italic>Result<\/jats:italic>. The max_WSS was 33.77\u2009kPa in the most extensive deformation. The highest WSS region on the plaque surface was also the highest PWS region. The max_PWS in a 12% stretch was 55.11\u2009kPa, which was lower than the rupture threshold. The max_VWTS of the cap in 12% stretch which approached the fracture stress level was 116.75\u2009kPa. Moreover, the vessel\u2019s max_VWTS values in 10% and 12% stretch were 554.21 and 855.19\u2009kPa. They were higher than the fracture threshold, which might cause media fracture. Meanwhile, the 7% stretched strain was 0.29, closed to the smallest experimental green strains at rupture. <jats:italic>Conclusion.<\/jats:italic> The carotid arteries\u2019 higher stretch generated the higher stress level of the plaque. Cervical rotatory manipulation might cause plaque at a high risk of rupture in deformation after 12% stretch and more. Lower deformation of the plaque and artery caused by the high\u2010speed, low\u2010amplitude spinal manipulation might be safer.<\/jats:p>","DOI":"10.1155\/2021\/8239326","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T15:08:42Z","timestamp":1610377722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rupture Risk Assessment of Cervical Spinal Manipulations on Carotid Atherosclerotic Plaque by a 3D Fluid\u2010Structure Interaction Model"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5016-2663","authenticated-orcid":false,"given":"Yili","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-085X","authenticated-orcid":false,"given":"Shaoqun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2415-1076","authenticated-orcid":false,"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-5994","authenticated-orcid":false,"given":"Yonghua","family":"Lao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5001-6375","authenticated-orcid":false,"given":"Xuecheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-7206","authenticated-orcid":false,"given":"Xiaoyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5822-2739","authenticated-orcid":false,"given":"Qiming","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8910-7466","authenticated-orcid":false,"given":"Yikai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,2]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199608010-00007"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2009.11.004"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.6.1213"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000069329.70061.68"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2010.03.007"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2012.03.005"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1356-689X(02)00155-8"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-4754(03)00074-5"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.math.2014.11.012"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.558676"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2016.06.002"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2009.07.009"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.4001028"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.484766"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.01.011"},{"key":"e_1_2_10_16_2","doi-asserted-by":"crossref","unstructured":"DeepaT. K. BinuL. S. andSukeshK. A. Modelling blood flow and analysis of atherosclerotic plaque rupture under g-force 1 2009 3rd International Conference on Bioinformatics and Biomedical Engineering June 2009 Beijing China no. 1 1\u20134 https:\/\/doi.org\/10.1109\/icbbe.2009.5163077 2-s2.0-72749114998.","DOI":"10.1109\/ICBBE.2009.5163077"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.1800557"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1529-9430(01)00007-9"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2012.09.005"},{"volume-title":"Clinical Study on the Treatment of Soft Tissue Injury with Combination of TCM and Western Medicine","year":"2002","author":"Feng T. Y.","key":"e_1_2_10_20_2"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/20307071"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2008.07.011"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.510644"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.1762898"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32321"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-016-1055-1"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.4.1179"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00005.2008"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606310103"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2011.03.033"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2011.07.012"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/8239326.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/8239326.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/8239326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T12:12:16Z","timestamp":1735647136000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/8239326"}},"subtitle":[],"editor":[{"given":"Muhammad Shahbaz","family":"Yousaf","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/8239326"],"URL":"https:\/\/doi.org\/10.1155\/2021\/8239326","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8239326"}}