{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:11:58Z","timestamp":1767168718445,"version":"build-2238731810"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2021,10,6]]},"abstract":"<jats:p>\n                    The study aimed to investigate the dynamic changes of percutaneous partial oxygen pressure during the development and evolution of a hypertrophic scar. Twenty cases of hypertrophic scar patients at different stages were selected. A percutaneous oxygen monitor was used to measure oxygen partial pressure in the scar and normal skin tissue at 14, 30, 60, and 90 days after surgery. The changes of oxygen partial pressure, tissue structure, HIF-1\u03b1, and VEGF expression in the scar tissue were observed, and the correlation was analyzed. In the scar maturation process, with the prolongation of time, the partial oxygen pressure in the tissue increased gradually. The expression intensity of HIF-1\u03b1 and VEGF decreased gradually, HIF-1\u03b1 was positively correlated with VEGF (r\u2009=\u20090.98,\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.01<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ), there was a negative correlation between oxygen partial pressure and HIF-1 \u03b1 expression (r\u2009=\u2009\u22120.92,\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.01<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ), and it was negatively correlated with VEGF (r\u2009=\u2009\u22120.88,\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.01<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). TcPO2 measurement can be used to assess scar maturity; HIF-1 \u03b1 and VEGF may play an essential role in regulating partial oxygen pressure in the scar tissue.\n                  <\/jats:p>","DOI":"10.1155\/2021\/8241193","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T21:25:35Z","timestamp":1633555535000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Application of Intelligent Monitoring of Percutaneous Partial Oxygen Pressure in Evaluating the Evolution of Scar Hyperplasia"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-9770","authenticated-orcid":true,"given":"Wanle","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Burn and Plastic Surgery, Qinghai Provincial People\u2019s Hospital, Xining, Qinghai 810000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-8317","authenticated-orcid":true,"given":"Mejia","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, Qinghai Provincial People\u2019s Hospital, Xining, Qinghai 810000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4149-6482","authenticated-orcid":true,"given":"Yan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, Qinghai Provincial People\u2019s Hospital, Xining, Qinghai 810000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0298-0052","authenticated-orcid":true,"given":"Zhuoma","family":"Dawa","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, Qinghai Provincial People\u2019s Hospital, Xining, Qinghai 810000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9077-0495","authenticated-orcid":true,"given":"Junjie","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, Qinghai Provincial People\u2019s Hospital, Xining, Qinghai 810000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3111-3916","authenticated-orcid":true,"given":"Yanan","family":"An","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, Qinghai Provincial People\u2019s Hospital, Xining, Qinghai 810000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2020.08.023"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.4236\/ojog.2019.98112"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1088\/1755-1315\/267\/5\/052015"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s10854-018-00598-x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1080\/00150193.2019.1621709"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.2095-4352.2019.05.011"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688551"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2021.24.e459"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s12613-019-1918-2"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.15561\/20755279.2021.0305"}],"updated-by":[{"DOI":"10.1155\/2023\/9781241","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"record-id":"54918"},{"DOI":"10.1155\/2023\/9781241","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000}}],"container-title":["Journal 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