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Acute myocardial infarction (AMI) is a common cardiovascular disease with high disability and mortality. Circular RNAs (circRNAs) are implicated in the pathomechanism of multiple human diseases, including AMI. This study intended to explore the function and working mechanism of a novel circRNA circ_0023461 in hypoxia\u2010induced cardiomyocytes. <jats:italic>Methods<\/jats:italic>. Reverse transcription\u2010quantitative polymerase chain reaction (RT\u2010qPCR) and Western blot assay were implemented to detect RNA and protein expression. Cell counting kit\u20108 (CCK8) assay and 5\u2010ethynyl\u20102\u2009<jats:sup>\u2032<\/jats:sup>\u2010deoxyuridine (Edu) assay were conducted to analyze cell viability and proliferation ability. Cell migration and apoptosis were assessed by Transwell assay and flow cytometry. Cell oxidative stress was analyzed using the commercial kits. Enzyme\u2010linked immunosorbent assay (ELISA) was conducted to analyze cell inflammation. Cell glycolytic metabolism was evaluated using the commercial kits. Dual\u2010luciferase reporter assay and RNA pull\u2010down assay were conducted to verify the intermolecular interactions. <jats:italic>Results<\/jats:italic>. circ_0023461 expression was upregulated in AMI patients and hypoxia\u2010induced AC16 cells. Hypoxia restrained the viability, proliferation, migration, and glycolysis and induced the apoptosis, oxidative stress, and inflammation of AC16 cells, and these effects were attenuated by the silence of circ_0023461. MicroRNA\u2010370\u20103p (miR\u2010370\u20103p) was verified as a target of circ_0023461, and circ_0023461 silencing\u2010mediated protective effects in hypoxia\u2010induced cardiomyocytes were partly alleviated by the knockdown of miR\u2010370\u20103p. miR\u2010370\u20103p interacted with the 3\u2009<jats:sup>\u2032<\/jats:sup> untranslated region (3\u2009<jats:sup>\u2032<\/jats:sup> UTR) of phosphodiesterase 4D (PDE4D), and PDE4D overexpression partly reversed miR\u2010370\u20103p overexpression\u2010induced protective effects in hypoxia\u2010induced cardiomyocytes. circ_0023461 can upregulate PDE4D expression by acting as a molecular sponge for miR\u2010370\u20103p in AC16 cells. <jats:italic>Conclusion<\/jats:italic>. circ_0023461 knockdown attenuated hypoxia\u2010induced dysfunction in AC16 cells partly by targeting the miR\u2010370\u20103p\/PDE4D 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