{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T17:06:58Z","timestamp":1774890418872,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LGJ18H160002"],"award-info":[{"award-number":["LGJ18H160002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2021,12,15]]},"abstract":"<jats:p>Objective. Given its role in the regulation of calcium and PTH levels, vitamin D was presumed as a potential predictor of postoperative hypoparathyroidism. However, the reports about their association were controversial. This study aims to reveal the relationship between preoperative vitamin D and postoperative parathyroid hormone (PTH). Methods. A total of 242 papillary thyroid cancer (PTC) patients who underwent total thyroidectomy (TT) during the period from June 2016 to December 2017 at our hospital were enrolled. Patients were divided into two groups, HypoP and Non-HypoP groups, based on postoperative PTH\u2009&lt;\u200915.0 or \u226515.0\u2009pg\/mL, and \u0394PTH50+ and \u0394PTH50\u2212 groups, based on postoperative PTH reduction ratio\u2009\u2265\u200950% or &lt;50%. Clinicopathological features and laboratory data were compared between two sets of groups. Results. Preoperative PTH level was lower in the HypoP group than in the Non-HypoP group (42.83 vs. 47.52\u2009pg\/mL, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.018<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). No significant difference of vitamin D insufficiency was found between the HypoP and Non-HypoP groups (80.8% vs. 74.1%, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.226<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The rate of vitamin D insufficiency was higher in the \u0394PTH50+ group than in the \u0394PTH50\u2212 group (82.6% vs. 68.4%, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.010<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). By multivariate logistic regression analysis, vitamin D insufficiency was an independent predictor of postoperative PTH reduction ratio\u2009\u2265\u200950% (OR\u2009=\u20092.2, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.017<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Conclusion. Vitamin D insufficiency is not associated with postoperative PTH in PTC patients undergoing TT. However, vitamin D insufficiency is an independent predictor of postoperative PTH reduction ratio.<\/jats:p>","DOI":"10.1155\/2021\/8657918","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T02:05:25Z","timestamp":1639620325000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Vitamin D Insufficiency Predicts Susceptibility of Parathyroid Hormone Reduction after Total Thyroidectomy in Thyroid Cancer Patients"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2004-8282","authenticated-orcid":true,"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, No. 1 East Banshan Road, Hangzhou 310022, Zhejiang, China"},{"name":"Key Laboratory of Head and Neck Cancer Translational Research of Zhejiang Province, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, No. 1 East Banshan Road, Hangzhou 310022, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hangzhou Fuyang Women and Children Hospital, No. 25 Hengliangting Road, Hangzhou 311400, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1729-9323","authenticated-orcid":true,"given":"Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, No. 1 East Banshan Road, Hangzhou 310022, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1001\/jamaoncol.2018.2706","article-title":"Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2016: a systematic analysis for the global burden of disease study","volume":"4","author":"Global Burden of Disease Cancer Collaboration","year":"2018","journal-title":"JAMA Oncology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.05.019"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-019-01064-z"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4158\/ep-2019-0544"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2017.09.03"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-017-9424-1"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-019-01748-3"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12128"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.2018.0336140319"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8875257"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0309"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24159"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24583"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2017.03.002"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4383-9"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06211-4"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.08.019"},{"key":"19","first-page":"21","article-title":"Stratifying the risk factors for hypoparathyroidism after total thyroidectomy. 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