{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:51:44Z","timestamp":1774533104979,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tai\u2019an Science and Technology Plan","award":["2020NS129"],"award-info":[{"award-number":["2020NS129"]}]},{"name":"Tai\u2019an Science and Technology Plan","award":["2018NS0116"],"award-info":[{"award-number":["2018NS0116"]}]},{"name":"Tai\u2019an Science and Technology Plan","award":["ZR2020MH312"],"award-info":[{"award-number":["ZR2020MH312"]}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2020NS129"],"award-info":[{"award-number":["2020NS129"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2018NS0116"],"award-info":[{"award-number":["2018NS0116"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH312"],"award-info":[{"award-number":["ZR2020MH312"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2021,12,8]]},"abstract":"Objective. To investigate the quantity of CD4+T, CD4+T, CD8+T, and \u03b3\u03b4T cells in peripheral blood of HIV-infected\/AIDS patients as well as to explore the possible role of CD4\/CD8 ratio and \u03b3\u03b4T cells in the progression of HIV\/AIDS, aimed at providing evidence for the diagnosis and treatment of AIDS. Methods. The quantity levels of CD3+T cells, CD4+T cells, CD8+T cells, and \u03b3\u03b4T cells in peripheral blood of 46 HIV-infected\/AIDS patients and 30 healthy controls were detected by using flow cytometry. Results. The count of CD3+T, CD4+T, CD8+T, and \u03b3\u03b4T cells (\n \n \n x<\/a:mi>\n \u00af<\/a:mo>\n <\/a:mover>\n \u00b1<\/a:mo>\n s<\/a:mi>\n <\/a:math>\n <\/jats:inline-formula>, A\/\u03bcl) in the peripheral blood was \n \n 1183.64<\/e:mn>\n \u00b1<\/e:mo>\n 132.58<\/e:mn>\n <\/e:math>\n <\/jats:inline-formula>, \n \n 278.39<\/g:mn>\n \u00b1<\/g:mo>\n 122.38<\/g:mn>\n <\/g:math>\n <\/jats:inline-formula>, \n \n 863.13<\/i:mn>\n \u00b1<\/i:mo>\n 82.38<\/i:mn>\n <\/i:math>\n <\/jats:inline-formula>, and \n \n 22.53<\/k:mn>\n \u00b1<\/k:mo>\n 1.74<\/k:mn>\n <\/k:math>\n <\/jats:inline-formula> in the experimental group as well as \n \n 1456.46<\/m:mn>\n \u00b1<\/m:mo>\n 124.37<\/m:mn>\n <\/m:math>\n <\/jats:inline-formula>, \n \n 788.74<\/o:mn>\n \u00b1<\/o:mo>\n 189.67<\/o:mn>\n <\/o:math>\n <\/jats:inline-formula>, \n \n 569.61<\/q:mn>\n \u00b1<\/q:mo>\n 46.49<\/q:mn>\n <\/q:math>\n <\/jats:inline-formula>, and \n \n 10.96<\/s:mn>\n \u00b1<\/s:mo>\n 0.28<\/s:mn>\n <\/s:math>\n <\/jats:inline-formula> in the control group, respectively. The \n \n p<\/u:mi>\n <\/u:math>\n <\/jats:inline-formula> values of the two groups were <0.005 after the \n \n t<\/w:mi>\n <\/w:math>\n <\/jats:inline-formula>-test, revealing a statistically significant difference. The proportion of CD3+T, CD4+T, CD8+T, and \u03b3\u03b4T cells in total lymphocytes in the two groups (\n \n \n x<\/y:mi>\n \u00af<\/y:mo>\n <\/y:mover>\n \u00b1<\/y:mo>\n s<\/y:mi>\n <\/y:math>\n <\/jats:inline-formula>, %) was \n \n 71.83<\/cb:mn>\n \u00b1<\/cb:mo>\n 5.37<\/cb:mn>\n <\/cb:math>\n <\/jats:inline-formula>, \n \n 13.39<\/eb:mn>\n \u00b1<\/eb:mo>\n 2.23<\/eb:mn>\n <\/eb:math>\n <\/jats:inline-formula>, \n \n 62.93<\/gb:mn>\n \u00b1<\/gb:mo>\n 5.81<\/gb:mn>\n <\/gb:math>\n <\/jats:inline-formula>, and \n \n 3.67<\/ib:mn>\n \u00b1<\/ib:mo>\n 0.87<\/ib:mn>\n <\/ib:math>\n <\/jats:inline-formula> in the experimental group, respectively. In the control group, the values were expressed as \n \n 66.72<\/kb:mn>\n \u00b1<\/kb:mo>\n 5.48<\/kb:mn>\n <\/kb:math>\n <\/jats:inline-formula>, \n \n 42.77<\/mb:mn>\n \u00b1<\/mb:mo>\n 3.38<\/mb:mn>\n <\/mb:math>\n <\/jats:inline-formula>, \n \n 31.41<\/ob:mn>\n \u00b1<\/ob:mo>\n 3.62<\/ob:mn>\n <\/ob:math>\n <\/jats:inline-formula>, and \n \n 1.73<\/qb:mn>\n \u00b1<\/qb:mo>\n 0.36<\/qb:mn>\n <\/qb:math>\n <\/jats:inline-formula>, respectively. After performing the \n \n t<\/sb:mi>\n <\/sb:math>\n <\/jats:inline-formula>-test, \n \n p<\/ub:mi>\n <\/ub:math>\n <\/jats:inline-formula> values in the two groups were <0.005 except CD3+T, with statistically significant differences. Besides, CD4\/CD8 was \n \n 0.33<\/wb:mn>\n \u00b1<\/wb:mo>\n 0.11<\/wb:mn>\n <\/wb:math>\n <\/jats:inline-formula> in the experimental group and \n \n 1.48<\/yb:mn>\n \u00b1<\/yb:mo>\n 0.29<\/yb:mn>\n <\/yb:math>\n <\/jats:inline-formula> in the control group, \n \n t<\/ac:mi>\n =<\/ac:mo>\n 26.528<\/ac:mn>\n ,<\/ac:mo>\n p<\/ac:mi>\n <<\/ac:mo>\n 0.001<\/ac:mn>\n <\/ac:math>\n <\/jats:inline-formula>, exhibiting a significant statistical difference. Conclusion. HIV infection induces the activation and proliferation of CD8+T and \u03b3\u03b4T cells, contributing to the decrease of CD4+T cells, while CD8+T and \u03b3\u03b4T cells are involved in the immune response and tissue damage after HIV infection.<\/jats:p>","DOI":"10.1155\/2021\/8746264","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T20:05:19Z","timestamp":1638993919000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["CD3+T, CD4+T, CD8+T, and CD4+T\/CD8+T Ratio and Quantity of \u03b3\u03b4T Cells in Peripheral Blood of HIV-Infected\/AIDS Patients and Its Clinical Significance"],"prefix":"10.1155","volume":"2021","author":[{"given":"Nange","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Second Affiliated Hospital of Shandong First Medical University, Taian City 271000, Shandong Province, China"},{"name":"Department of Laboratory Medicine, Xianyang Central Hospital, Xianyang City, 712000 Shanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Second Affiliated Hospital of Shandong First Medical University, Taian City 271000, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Yingsheng District, Tai\u2019an Central Hospital, Taian City 271000, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Xianyang Central Hospital, Xianyang City, 712000 Shanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0992-6016","authenticated-orcid":true,"given":"Keqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Second Affiliated Hospital of Shandong First Medical University, Taian City 271000, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2016.02.010"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0254-6450.2020.01.018"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws321"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000224"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2147\/HIV.S46585"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493571"},{"key":"7","first-page":"1785","article-title":"Western blotting was used to detect ZAP-70 molecule from \u03b3\u03b4\u03a4 cells in peripheral blood","volume":"12","author":"K. 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Wang","year":"2004","journal-title":"Chinese Journal of AIDS & STD"}],"updated-by":[{"DOI":"10.1155\/2023\/9840307","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"record-id":"47912"},{"DOI":"10.1155\/2023\/9840307","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000}}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/8746264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/8746264.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/8746264.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T20:05:47Z","timestamp":1638993947000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2021\/8746264\/"}},"subtitle":[],"editor":[{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,12,8]]},"references-count":34,"alternative-id":["8746264","8746264"],"URL":"https:\/\/doi.org\/10.1155\/2021\/8746264","relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9840307","asserted-by":"object"}]},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,8]]}}}