{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:28:24Z","timestamp":1760956104974,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T00:00:00Z","timestamp":1621728000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2021,5,23]]},"abstract":"<jats:p>Background and Aims. Thrombocytopenia is a common complication in patients with chronic hepatitis C virus (HCV) that increases the risk of bleeding. We aimed to analyze the hematologic effects of the new direct-acting antiviral (DAA) therapy, particularly on the platelet count in chronic HCV-infected patients with thrombocytopenia. Patients and Methods. One hundred thrombocytopenic patients chronically infected with HCV were included in a prospective study. All patients were eligible for receiving anti-HCV treatment with sofosbuvir-based regimens for 12 weeks, according to the protocol of the National Program for treatment of HCV in Egypt sponsored by the Ministry of Health. Results. At the end of treatment (EOT), there was a highly significant increase in platelet count (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>), a significant increase in white blood cells (WBCs) count (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>\u2264<\/c:mo>\n                        <c:mn>0.032<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), and a highly significant decrease in hemoglobin level (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) as compared to pretreatment levels. Patients with mild to moderate hepatic fibrosis had significantly higher median and interquartile range (IQR) platelet count at baseline and EOT than those with advanced fibrosis and cirrhosis (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>\u2264<\/g:mo>\n                        <g:mn>0.023<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula> and <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.001<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, respectively). There was more elevation in platelet count at EOT in patients with mild to moderate fibrosis than those with advanced fibrosis and cirrhosis. Out of the hundred patients, 73% showed improvement of platelet count, while 27% showed no improvement or even decrease in the platelet count. Conclusion. Sofosbuvir-based DAA therapy is a highly effective and safe treatment regimen that results in the improvement of platelet count in thrombocytopenic patients, particularly in mild to moderate stages of hepatic fibrosis.<\/jats:p>","DOI":"10.1155\/2021\/8811203","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T19:05:08Z","timestamp":1621969508000},"page":"1-10","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Direct-Acting Antiviral Therapy on Thrombocytopenic Patients with Hepatitis C Virus-Related Chronic Liver Disease"],"prefix":"10.1155","volume":"2021","author":[{"given":"Mahmoud","family":"Saif-Al-Islam","sequence":"first","affiliation":[{"name":"Tropical Medicine and Gastroenterology Department, Sohag University Hospital, Faculty of Medicine, Sohag, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-668X","authenticated-orcid":true,"given":"Usama M.","family":"Abdelaal","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Sohag University Hospital, Faculty of Medicine, Sohag, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Adel","family":"Younis","sequence":"additional","affiliation":[{"name":"Clinical and Chemical Pathology Department, Sohag University Hospital, Faculty of Medicine, Sohag, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisham A.","family":"Alghany Algahlan","sequence":"additional","affiliation":[{"name":"Diagnostic Radiology Department, Sohag University Hospital, Faculty of Medicine, Sohag, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safaa","family":"Khalaf","sequence":"additional","affiliation":[{"name":"Tropical Medicine and Gastroenterology Department, Sohag University Hospital, Faculty of Medicine, Sohag, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450107"},{"issue":"1","key":"2","first-page":"35","article-title":"Global surveillance and control of hepatitis C. 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