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Especially, the current body of knowledge about COVID\u201019 therapeutics needs more data regarding drug effectiveness and safety in the severely ill patients with comorbidities. In the present article, we retrospectively analyze data from 61 patients that received treatment with chloroquine, lopinavir\/ritonavir, both drugs administered together, or a standard treatment with no antiviral drugs, and the study was carried in severely ill patients. We found that either drug is ineffective at treating COVID\u201019, as they are not able to reduce hospitalization length, mortality, C\u2010reactive protein (CRP), lactate dehydrogenase (LDH), d\u2010Dimer, or ferritin, or to enhance gasometric parameters, lymphocytes, total leukocytes, and neutrophil levels, whereas both drugs administered together decrease circulating lymphocytes, increase LDH and ferritin levels, and more importantly, enhance mortality. In this way, our results show that both drugs are ineffective and even potentially harmful alternatives against SARS\u2010CoV\u20102.<\/jats:p>","DOI":"10.1155\/2021\/8821318","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:47:44Z","timestamp":1612831664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Both Chloroquine and Lopinavir\/Ritonavir Are Ineffective for COVID\u201019 Treatment and Combined Worsen the Pathology: A Single\u2010Center Experience with Severely Ill Patients"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8199-0568","authenticated-orcid":false,"given":"Fernando","family":"Sevilla-Castillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3232-6112","authenticated-orcid":false,"given":"Oscar J.","family":"Roque-Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8317-7586","authenticated-orcid":false,"given":"Fernanda","family":"Romero-Lechuga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5214-1647","authenticated-orcid":false,"given":"Mario F.","family":"G\u00f3mez-N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7668-4638","authenticated-orcid":false,"given":"Mariel","family":"Castillo-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7394-1109","authenticated-orcid":false,"given":"Diana","family":"Medina-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1723-2871","authenticated-orcid":false,"given":"Perla Oriana","family":"Rom\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3745-2791","authenticated-orcid":false,"given":"Jorge Rafael","family":"Flores-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5382-2866","authenticated-orcid":false,"given":"Juan Daniel","family":"M\u00e9ndez-Coca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0892-385X","authenticated-orcid":false,"given":"Daniela","family":"Monta\u00f1o-Olmos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9124-7241","authenticated-orcid":false,"given":"Karla Cecilia","family":"Farf\u00e1n-Lazos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1126-5031","authenticated-orcid":false,"given":"Miranda","family":"Tob\u00f3n-Cubillos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-2447","authenticated-orcid":false,"given":"Am\u00e9rica","family":"Viveros-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1286-2236","authenticated-orcid":false,"given":"Leonardo","family":"Torres-Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-7006","authenticated-orcid":false,"given":"Karla Y.","family":"Hern\u00e1ndez-Skewes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-7970","authenticated-orcid":false,"given":"Guillermo","family":"Montiel-Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8362-2304","authenticated-orcid":false,"given":"Shannat","family":"Ortega-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6951-2248","authenticated-orcid":false,"given":"Alberto N.","family":"Pe\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"e_1_2_10_1_2","unstructured":"Organization W. 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