{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:39:24Z","timestamp":1770226764001,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Owerko Centre of Alberta Children\u2019s Hospital Research Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:p>Background. Tic disorders may reflect impaired inhibitory control. This has been evaluated using different behavioural tasks, yielding mixed results. Our objective was to test inhibitory control in children with tics through simultaneous presentation of multiple, mobile stimuli. Methods. Sixty-four children with tics (mean age 12.4 years; 7.5-18.5) were evaluated using a validated robotic bimanual exoskeleton protocol (Kinarm) in an object-hit-and-avoid task, in which target and distractor objects moved across a screen and participants aimed to hit only the targets while avoiding distractors. Performance was compared to 146 typically developing controls (mean age 13 years; 6.1-19.9). The primary outcome was the percentage of distractors struck. Results. ANCOVA (age as covariate) showed participants struck significantly more distractors (participants without comorbid ADHD, 22.71% [SE 1.47]; participants with comorbid ADHD, 23.56% [1.47]; and controls, 15.59% [0.68]). Participants with comorbid ADHD struck significantly fewer targets (119.74 [2.77]) than controls, but no difference was found between participants without comorbid ADHD (122.66 [2.77]) and controls (127.00 [1.28]). Participants and controls did not differ significantly in movement speed and movement area. Just over 20% of participants with tics fell below the age-predicted norm in striking distractors, whereas fewer than 10% fell outside age-predicted norms in other task parameters. Conclusions. In children with tics (without comorbid ADHD), acting upon both targets and distractors suggests reduced ability to suppress responses to potential triggers for action. This may be related to increased sensorimotor noise or abnormal sensory gating.<\/jats:p>","DOI":"10.1155\/2021\/8825091","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T18:35:25Z","timestamp":1625250925000},"page":"1-13","source":"Crossref","is-referenced-by-count":3,"title":["Inhibitory Control Deficits in Children with Tic Disorders Revealed by Object-Hit-and-Avoid Task"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-2222","authenticated-orcid":true,"given":"Nicholas","family":"Cothros","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8640-3967","authenticated-orcid":true,"given":"Alex","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2217-0487","authenticated-orcid":true,"given":"Davide","family":"Martino","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0609-981X","authenticated-orcid":true,"given":"Sean P.","family":"Dukelow","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-7755","authenticated-orcid":true,"given":"Rachel L.","family":"Hawe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5209-3374","authenticated-orcid":true,"given":"Adam","family":"Kirton","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8077-8530","authenticated-orcid":true,"given":"Christos","family":"Ganos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charit\u00e9 University Hospital Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-9693","authenticated-orcid":true,"given":"Elaheh","family":"Nosratmirshekarlou","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8229-8431","authenticated-orcid":true,"given":"Tamara","family":"Pringsheim","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Psychiatry, Pediatrics and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23088"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.11.004"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00021"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-411546-0.00002-0"},{"key":"5","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.neubiorev.2017.05.006","article-title":"The puzzling question of inhibitory control in Tourette syndrome: a meta-analysis","volume":"80","author":"S. 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