{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:56:06Z","timestamp":1787849766450,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M641679"],"award-info":[{"award-number":["2018M641679"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the most common neurodegenerative disease, which is associated with extracellular deposition of amyloid\u2010<jats:italic>\u03b2<\/jats:italic> proteins (A<jats:italic>\u03b2<\/jats:italic>). It has been reported that triptolide (TP), an immunosuppressive and anti\u2010inflammatory agent extracted from a Chinese herb <jats:italic>Tripterygium wilfordii<\/jats:italic>, shows potential neuroprotective effects pertinent to AD. However, the clinical use of TP for AD could be hampered due to its high toxicity, instability, poor water solubility, and nonspecific biodistribution after administration. In this paper, we reported a kind of multiple\u2010coated PLGA nanoparticle with the entrapment of TP and surface coated by chitosan hydrochloride, Tween\u201080, PEG20000, and borneol\/mentholum eutectic mixture (MC\u2010PLGA\u2010TP\u2010NP) as a novel nasal brain targeting preparation for the first time. The obtained MC\u2010PLGA\u2010TP\u2010NP was 147.5 \u00b1 20.7\u2009nm with PDI of 0.263 \u00b1 0.075, zeta potential of 14.62 \u00b1 2.47\u2009mV, and the entrapment efficiency and loading efficiency of 93.14<jats:italic>%<\/jats:italic> \u00b1 4.75<jats:italic>%<\/jats:italic> and 1.17 \u00b1 0.08<jats:italic>%<\/jats:italic>, respectively. In comparison of TP, MC\u2010PLGA\u2010TP\u2010NP showed sustained\u2010release profile and better transcellular permeability to Caco\u20102 cells in vitro. In addition, our data showed that MC\u2010PLGA\u2010TP\u2010NP remarkably reduced the cytotoxicity, attenuated the oxidative stress, and inhibited the increase of the intracellular Ca<jats:sup>2+<\/jats:sup> influx in differentiated PC12 cells induced by A<jats:italic>\u03b2<\/jats:italic><jats:sub>1-42<\/jats:sub>. Therefore, it can be concluded that MC\u2010PLGA\u2010TP\u2010NP is a promising preparation of TP, which exerts a better neuroprotective activity in the AD cellular model.<\/jats:p>","DOI":"10.1155\/2021\/8825640","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T19:50:09Z","timestamp":1614282609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Multiple\u2010Coated PLGA Nanoparticles Loading Triptolide Attenuate Injury of a Cellular Model of Alzheimer\u2019s 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