{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:39:33Z","timestamp":1773283173789,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K10151"],"award-info":[{"award-number":["19K10151"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K09600"],"award-info":[{"award-number":["18K09600"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Sudachitin, which is a polymethoxylated flavonoid found in the peel of Citrus sudachi, has some biological activities. However, the effect of sudachitin on periodontal resident cells is still uncertain. The aim of this study was to examine if sudachitin could decrease the expression of inflammatory mediators such as cytokines, chemokines, or matrix metalloproteinase (MMP) in interleukin\u2010 (IL\u2010) 1<jats:italic>\u03b2<\/jats:italic>\u2010stimulated human periodontal ligament cells (HPDLC). Sudachitin inhibited IL\u20101<jats:italic>\u03b2<\/jats:italic>\u2010induced IL\u20106, IL\u20108, CXC chemokine ligand (CXCL)10, CC chemokine ligand (CCL)2, MMP\u20101, and MMP\u20103 production in HPDLC. On the other hand, tissue inhibitor of metalloproteinase\u2010 (TIMP\u2010) 1 expression was increased by sudachitin treatment. Moreover, we found that the nuclear factor\u2010 (NF\u2010) <jats:italic>\u03ba<\/jats:italic>B and protein kinase B (Akt) pathways in the IL\u20101<jats:italic>\u03b2<\/jats:italic>\u2010stimulated HPDLC were inhibited by sudachitin treatment. These findings indicate that sudachitin is able to reduce inflammatory mediator production in IL\u20101<jats:italic>\u03b2<\/jats:italic>\u2010stimulated HPDLC by inhibiting NF\u2010<jats:italic>\u03ba<\/jats:italic>B and Akt pathways.<\/jats:p>","DOI":"10.1155\/2021\/8826586","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T17:20:27Z","timestamp":1611940827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Polymethoxy Flavonoid Sudachitin Inhibits Interleukin\u20101<i>\u03b2<\/i>\u2010Induced Inflammatory Mediator Production in Human Periodontal Ligament 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